Henan Tianfu Chemical Co., Ltd.
China
Product Name: Prednisolone phosphate sodium
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
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Email: info@tianfuchem.com

125-02-0

125-02-0 structure

Name: Prednisolone Sodium Phosphate
Chemical Name: Prednisolone phosphate sodium
CAS Number: 125-02-0
Molecular Formula: C₂₁H₂₇Na₂O₈P
Molecular Weight: 484.388
Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
Create Date: 2018-05-10 08:00:00
Modify Date: 2026-07-01 07:32:15
Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].

Name	Prednisolone phosphate sodium
Synonyms	PREDNISONE SODIUM PHOSPHATE (11beta) predsolan Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI) )-9-Fluoro-11,21-dihydroxy-16-methyl-pregna-1,4,16-triene-3,20-dione PREDNISOLONESODIUMPHOSPHATE Pediapred 17,21-Trihydroxy-16&alpha 17,20&beta Inflamase prednisolon disodium phosphate PREDNISOLONE 21-PHOSPHATE, DISODIUM SALT Prednisolone sodium phosphate phortisolone prednisolone phosphate sodium prednisolone 21-(disodium phosphate) Optival prednesol 21-Tetrahydroxypregna-1,4-dien-3-one 21-Acetate Predsol PREDNISOLONE SODIUM PHOSPHATE Codelsol SODIUM PREDNISOLONE-21-PHOSPHATE Prednisolone Phosphate (sodium salt) Prednisolone (disodium phosphate) inflamase methyl-17,20:20,21-bis(methylenedioxy)-pregn-4-en-3-one prednisolone 21-disodium phosphate Prednisolone 21-Phosphate Disodium Salt MFCD07776968 Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11b)- (9CI) )-21-Chloro-9-fluoro-11-hydroxy-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione phosphate de 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-diméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yl]-2-oxoéthyle de disodium pregna-1,4-diene-3,20-dione,11,17-dihydroxy-21-(phosphonooxy)-,disodiumsalt 21-Tetrahydroxypregna-1,4-diene-3,20-dione-d3 METRETON e),disodiumsalt EINECS 204-722-9 PrednisoloneSodiumPhosphateBp Prednisolone phospha )-11,17,21-Trihydroxy-pregna-1,4,8-triene-3,20-dione Dinatrium-2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethylphosphat Solu-Predalone Hefasolon Hydroxy-3-oxo-androsta-1,4-diene-17&beta Predsolan Prednesol Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, sodium salt, (11β)- (1:2) Disodium (11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl phosphate )-11-Hydroxy-16-methyl-17,21-bis(1-oxoacetoxy)-pregna-1,4-diene-3,20-dione Prednisolone 21-sodium phosphate Phortisolone Prednisolone Series Base -8 / Phosphate disodium 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl phosphate optival 4-diene-3,20-dione,11-beta,17,21-trihydroxy-pregna-21-(dihydrogenphosphat predsol Hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-en-3-one Nitrite Hydroperoxy Dienogest Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-, 21-phosphate, disodium salt (6CI) 17,21-Trihydroxy-3,20-dioxo-cyclic-18,11-hemiacetal Pregn-4-en-18-al Triacetate 11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(Disodium phosphate) methyl-pregn-4-ene-3,20-dione 21-Acetate Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11.beta.) codelsol hydeltrasol 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(disodium phosphate) prednisolone21-phosphatedisodium sodiumprednisolonhosphate disodium [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate prozorin Prozorin Disodium Prednisolone 21-Phosphate prednisolonedisodiumphosphate Solucort solucort )-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-3-hydroxy-19-norpregna-1,3,5-trien-20-one-d3 Dojilon )-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-cboxylic Acid Metreton Ak-pred

Description	Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology
References	[1]. Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33(12): p. 1684-95. [2]. http://en.wikipedia.org/wiki/Prednisolone

Boiling Point	100 °C
Molecular Formula	C₂₁H₂₇Na₂O₈P
Molecular Weight	484.388
Flash Point	361.9ºC
Exact Mass	484.123901
PSA	156.83000
LogP	2.55100
Vapour Pressure	4.17E-21mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4153300

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(dihydrogen phosphate), disodium salt

CAS REGISTRY NUMBER :: 125-02-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H27-O8-P.2Na

MOLECULAR WEIGHT :: 484.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 22,1439,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5598 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)

Hazard Codes	Xi
Risk Phrases	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
HS Code	2937229000

HS Code	2937229000

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