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  • Product Name: D-Corydine
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  • Purity: 98.0%
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476-69-7

476-69-7 structure
476-69-7 structure
  • Name: D-Corydine
  • Chemical Name: (+)-corydaline
  • CAS Number: 476-69-7
  • Molecular Formula: C20H23NO4
  • Molecular Weight: 341.401
  • Catalog: Natural product Alkaloid
  • Create Date: 2018-08-26 17:45:14
  • Modify Date: 2024-01-02 07:22:35
  • Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine[1].

Name (+)-corydaline
Synonyms 4H-Dibenzo[de,g]quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (6aS)-
4H-Dibenzo[de,g]quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (S)-
(S)-5,6,6a,7-Tetrahydro-2,10.11-trimethoxy-6-methyl-4H-dibenzo[de,q]quinolin-1-ol
2,10,11-Trimethoxy-6aa-aporphin-1-ol
d-corydine
glaucentrin
glaucentrine
O11-Methylcorytuberine
(6aS)-2,10,11-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol
Description Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine[1].
Related Catalog
References

[1]. N.Ravanelli, et al. Alkaloids from Croton echinocarpus Baill.: Anti-HIV potential. South African Journal of Botany. 2016 Jan, 102: 153-156

Density 1.2±0.1 g/cm3
Boiling Point 505.7±50.0 °C at 760 mmHg
Melting Point 165-167ºC
Molecular Formula C20H23NO4
Molecular Weight 341.401
Flash Point 259.7±30.1 °C
Exact Mass 341.162720
PSA 51.16000
LogP 3.09
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.604

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CE1057000
CHEMICAL NAME :
6a-alpha-Aporphin-1-ol, 2,10,11-trimethoxy-
CAS REGISTRY NUMBER :
476-69-7
BEILSTEIN REFERENCE NO. :
0095568
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H23-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 31,44,1968

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476-69-7 structure

476-69-7

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664

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476-69-7 structure

476-69-7

Literature: Spaeth; Berger Chemische Berichte, 1931 , vol. 64, p. 2038,2043

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476-69-7 structure

476-69-7

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664

~%

476-69-7 structure

476-69-7

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664

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476-69-7 structure

476-69-7

Literature: Karimova, S. U.; Israilov, I. A.; Yunusov, M. S.; Yunusov, S. Yu. Chemistry of Natural Compounds, 1980 , vol. 16, # 2 p. 177 - 180 Khimiya Prirodnykh Soedinenii, 1980 , # 2 p. 224 - 228

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476-69-7 structure

476-69-7

Literature: Karimova, S. U.; Israilov, I. A.; Yunusov, M. S.; Yunusov, S. Yu. Chemistry of Natural Compounds, 1980 , vol. 16, # 2 p. 177 - 180 Khimiya Prirodnykh Soedinenii, 1980 , # 2 p. 224 - 228

~%

476-69-7 structure

476-69-7

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664

~%

476-69-7 structure

476-69-7

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664