D-Corydine

Modify Date: 2024-01-02 07:22:35

D-Corydine Structure
D-Corydine structure
 Common Name D-Corydine
CAS Number 476-69-7 Molecular Weight 341.401
Density 1.2±0.1 g/cm3 Boiling Point 505.7±50.0 °C at 760 mmHg
Molecular Formula C20H23NO4 Melting Point 165-167ºC
MSDS N/A Flash Point 259.7±30.1 °C

 Use of D-Corydine


Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine[1].

 Names

Name (+)-corydaline
Synonym More Synonyms

 D-Corydine Biological Activity

Description Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine[1].
Related Catalog
References

[1]. N.Ravanelli, et al. Alkaloids from Croton echinocarpus Baill.: Anti-HIV potential. South African Journal of Botany. 2016 Jan, 102: 153-156

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 505.7±50.0 °C at 760 mmHg
Melting Point 165-167ºC
Molecular Formula C20H23NO4
Molecular Weight 341.401
Flash Point 259.7±30.1 °C
Exact Mass 341.162720
PSA 51.16000
LogP 3.09
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.604

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CE1057000
CHEMICAL NAME :
6a-alpha-Aporphin-1-ol, 2,10,11-trimethoxy-
CAS REGISTRY NUMBER :
476-69-7
BEILSTEIN REFERENCE NO. :
0095568
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H23-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 31,44,1968

 Synthetic Route

(+)-corydine structure

(+)-corydine

CAS#:2505-56-8

~%

D-Corydine Structure

D-Corydine

CAS#:476-69-7

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664
diazomethane structure

diazomethane

CAS#:186581-53-3

~%

D-Corydine Structure

D-Corydine

CAS#:476-69-7

Literature: Spaeth; Berger Chemische Berichte, 1931 , vol. 64, p. 2038,2043
diazomethane structure

diazomethane

CAS#:186581-53-3

(S)-corytuberine structure

(S)-corytuberine

CAS#:517-56-6

~%

D-Corydine Structure

D-Corydine

CAS#:476-69-7

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664
diazomethane structure

diazomethane

CAS#:186581-53-3

(S)-corytuberine structure

(S)-corytuberine

CAS#:517-56-6

~%

isocorydine structure

isocorydine

CAS#:36284-37-4

D-Corydine Structure

D-Corydine

CAS#:476-69-7

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664
Formaldehyde structure

Formaldehyde

CAS#:50-00-0

(S)-norcorydine structure

(S)-norcorydine

CAS#:60661-35-0

~%

D-Corydine Structure

D-Corydine

CAS#:476-69-7

Literature: Karimova, S. U.; Israilov, I. A.; Yunusov, M. S.; Yunusov, S. Yu. Chemistry of Natural Compounds, 1980 , vol. 16, # 2 p. 177 - 180 Khimiya Prirodnykh Soedinenii, 1980 , # 2 p. 224 - 228
diazomethane structure

diazomethane

CAS#:186581-53-3

(+)-isocorytuberine structure

(+)-isocorytuberine

CAS#:6870-51-5

~%

D-Corydine Structure

D-Corydine

CAS#:476-69-7

Literature: Karimova, S. U.; Israilov, I. A.; Yunusov, M. S.; Yunusov, S. Yu. Chemistry of Natural Compounds, 1980 , vol. 16, # 2 p. 177 - 180 Khimiya Prirodnykh Soedinenii, 1980 , # 2 p. 224 - 228
Tartaric acid structure

Tartaric acid

CAS#:87-69-4

(+)-corydine structure

(+)-corydine

CAS#:2505-56-8

~%

D-Corydine Structure

D-Corydine

CAS#:476-69-7

2,10,11-trimethoxy-6-methyl-6aβ-aporphan-1-ol structure

2,10,11-trimeth...

CAS#:55056-92-3

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664
diazomethane structure

diazomethane

CAS#:186581-53-3

Diethyl ether structure

Diethyl ether

CAS#:60-29-7

Corytuberine structure

Corytuberine

CAS#:71630-07-4

~%

D-Corydine Structure

D-Corydine

CAS#:476-69-7

Literature: Gadamer Archiv der Pharmazie (Weinheim, Germany), 1911 , vol. 249, p. 664

 Synonyms

4H-Dibenzo[de,g]quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (6aS)-
4H-Dibenzo[de,g]quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (S)-
(S)-5,6,6a,7-Tetrahydro-2,10.11-trimethoxy-6-methyl-4H-dibenzo[de,q]quinolin-1-ol
2,10,11-Trimethoxy-6aa-aporphin-1-ol
d-corydine
glaucentrin
glaucentrine
O11-Methylcorytuberine
(6aS)-2,10,11-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol
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