Name | 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate |
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Synonyms |
Fluphenazine depot
1-decanoyloxy-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethane Modecate Fluphenaline decanoate Fluphenazindecanoat Moditen-depo Fluorophenazine decanoate Dapotum D Fluphenazine decanoate fluphenazine O-decanoate Flufenazine decanoate Fluphenazindecanat Moditen depot |
Description | Fluphenazine decanoate is a long-acting phenothiazine neuroleptic that used to treat schizophrenia. Fluphenazine decanoate is also a high and continuous dopamine D2 receptor blocker[1][2][3]. |
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Related Catalog | |
Target |
Dopamine D2 receptor[2] |
In Vivo | Six female Persian onagers (Equus hemionus onager) are treated with Fluphenazine decanoate (0.1 mg/kg IM) or saline control. Urinary cortisol, progesterone, estrogen metabolites and behavior are monitored, and follicular dynamics are examined using ultrasonography until ovulation. Onagers demonstrate significantly lower cortisol concentrations when treated with Fluphenazine decanoate (6.61 ng/mg creatinine) compared to saline (9.73 ng/mg creatinine). There are no differences in peak estrogen or progesterone concentrations between the two groups, and all animals ovulate within the expected time frame following Fluphenazine decanoate treatment. However, some onagers exhibit only minor reductions in cortisol secretion and one treated female demonstrates a suppressed luteal progesterone peak, indicating a possible reproductive cost to Fluphenazine decanoate administration[1]. |
References |
Density | 1.149 g/cm3 |
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Boiling Point | 658.1ºCat 760 mmHg |
Melting Point | 30-32° |
Molecular Formula | C32H44F3N3O2S |
Molecular Weight | 591.77100 |
Flash Point | 351.8ºC |
Exact Mass | 591.31100 |
PSA | 61.32000 |
LogP | 7.94050 |
Index of Refraction | 1.537 |
Storage condition | 2-8℃ |
Water Solubility | Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Hazard Codes | Xn |
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RIDADR | UN 3249 |
RTECS | HE0525000 |
Packaging Group | II |
Hazard Class | 6.1(a) |
HS Code | 3003909090 |
HS Code | 3003909090 |
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