5002-47-1

• 常用中文名：癸氟奋乃静
• 常用英文名：Fluphenazine decanoate
• CAS号：5002-47-1
• 分子式：C₃₂H₄₄F₃N₃O₂S
• 分子量：591.77100
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-03-08 08:00:00
• 更新时间：2024-01-02 16:53:01
• Fluphenazine decanoate 是一种长效的吩噻嗪抗精神病药,用于治疗精神分裂症。Fluphenazine decanoate 也是一种高度且连续的多巴胺 D2 受体阻滞剂。

名称

• 中文名: 癸氟奋乃静
• 英文名: 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate
• 中文别名: 保利坤; 4-[3-[2-(三氟甲基)-10H-吩噻嗪-10-基]丙基]-1-哌嗪乙醇癸酸酯
• 英文别名: Fluphenazine depot; 1-decanoyloxy-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethane; Modecate; Fluphenaline decanoate; Fluphenazindecanoat; Moditen-depo; Fluorophenazine decanoate; Dapotum D; Fluphenazine decanoate; fluphenazine O-decanoate; Flufenazine decanoate; Fluphenazindecanat; Moditen depot

物化性质

• 密度: 1.149 g/cm3
• 沸点: 658.1ºCat 760 mmHg
• 熔点: 30-32°
• 分子式: C₃₂H₄₄F₃N₃O₂S
• 分子量: 591.77100
• 闪点: 351.8ºC
• 精确质量: 591.31100
• PSA: 61.32000
• LogP: 7.94050
• 折射率: 1.537
• 储存条件: 2-8℃
• 水溶解性: Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:9

  4.可旋转化学键数量:16

  5.互变异构体数量:无

  6.拓扑分子极性表面积:61.3

  7.重原子数量:41

  8.表面电荷:0

  9.复杂度:765

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Fluphenazine decanoate 是一种长效的吩噻嗪抗精神病药,用于治疗精神分裂症。Fluphenazine decanoate 也是一种高度且连续的多巴胺 D2 受体阻滞剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 靶点:

  Dopamine D2 receptor[2]

• 体内研究: 六只雌性波斯水牛(Equaus hemionus onager)用癸酸氟苯那津(0.1 mg/kg IM)或生理盐水对照。监测尿皮质醇、孕酮、雌激素代谢产物和行为,用超声检查卵泡动力学直到排卵。与生理盐水(9.73 ng/mg肌酐)相比,服用癸酸氟苯那津(6.61 ng/mg肌酐)的运动员皮质醇浓度显著降低。两组间雌激素或孕酮峰值浓度没有差异,所有动物在癸酸氟奋乃静治疗后的预期时间内排卵。然而,一些吸食者的皮质醇分泌只有轻微的减少,一个接受治疗的女性显示黄体孕酮峰值被抑制,这表明使用癸酸氟奋乃嗪可能会造成生殖成本[1]。
• 参考文献:

  [1]. Wagman JD, et al. The effect of fluphenazine decanoate on glucocorticoid production, reproductive cyclicity, and the behavioral stress response in the Persian onager (Equus hemionus onager). Zoo Biol. 2015 Nov;34(6):525-34.

  [2]. Uchida H, et al. Dose and dosing frequency of long-acting injectable antipsychotics: a systematic review of PET and SPECT data and clinical implications. J Clin Psychopharmacol. 2014 Dec;34(6):728-35.

  [3]. Weiss RB, et al. Long-acting neuroleptic use for reproductive management of non-domestic ungulates using the domestic goat (Capra hircus) as a model. Zoo Biol. 2014 May-Jun;33(3):204-11.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HE0525000 CHEMICAL NAME : Decanoic acid, 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl )- 1-piperazinyl)ethyl ester CAS REGISTRY NUMBER : 5002-47-1 LAST UPDATED : 199612 DATA ITEMS CITED : 16 MOLECULAR FORMULA : C32-H44-F3-N3-O2-S MOLECULAR WEIGHT : 591.85 WISWESSER LINE NOTATION : T C666 BN ISJ EXFFF B3- AT6N DNTJ D2OV9 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - man DOSE/DURATION : 46 mg/kg/5Y-I TOXIC EFFECTS : Behavioral - muscle contraction or spasticity TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human DOSE/DURATION : 179 ug/kg TOXIC EFFECTS : Behavioral - antipsychotic TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - woman DOSE/DURATION : 21 mg/kg/6D-I TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - changes in structure or function of salivary glands Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - man DOSE/DURATION : 1071 ug/kg/12D-I TOXIC EFFECTS : Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - sweating TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 19 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 576 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Skin and Appendages - hair TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Skin and Appendages - hair TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 46 mg/kg/52W-I TOXIC EFFECTS : Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 82 mg/kg/52W-I TOXIC EFFECTS : Blood - normocytic anemia Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - changes in prostate weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 230 mg/kg SEX/DURATION : male 4 week(s) pre-mating female 2 week(s) pre-mating female 1-7 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 5 mg/kg SEX/DURATION : female 17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 25 mg/kg SEX/DURATION : female 17 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - delayed effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 5 mg/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - sex ratio MUTATION DATA TEST SYSTEM : Rodent - rat DOSE/DURATION : 20 mg/kg/12W (Intermittent) REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 244,331,1990 *** REVIEWS *** TOXICOLOGY REVIEW ABPYBL Advances in Biochemical Psychopharmacology. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1969- Volume(issue)/page/year: 9,301,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5576 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 794 (estimated) No. of Female Employees: 419 (estimated)

安全

• 危害码 (欧洲): Xn
• 危险品运输编码: UN 3249
• RTECS号: HE0525000
• 包装等级: II
• 危险类别: 6.1(a)
• 海关编码: 3003909090

海关

海关编码	3003909090