79778-41-9
79778-41-9 structure
- Name: Neridronate
- Chemical Name: neridronate sodium hydrate
- CAS Number: 79778-41-9
- Molecular Formula: C6H17NO7P2
- Molecular Weight: 277.149
- Catalog: Organic raw materials Organic phosphine compound
- Create Date: 2018-03-06 08:00:00
- Modify Date: 2024-01-07 05:30:59
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Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Paget’s disease of bone (PDB). Neridronate is effective also in other skeletal diseases such as osteoporosis, algodystrophy, hypercalcemia of malignancy, and bone metastases[1][2].
| Name | neridronate sodium hydrate |
|---|---|
| Synonyms |
(6-Amino-1-hydroxy-1,1-hexanediyl)bis(phosphonic acid)
Neridronic 6-amino-1-hydroxyhexane-1,1-diphosphonic acid NERIXIA 6-amino-1-hydroxy-1,1-hexylidenebisphosphonic acid Phosphonic acid, (6-amino-1-hydroxyhexylidene)bis- (6-amino-1-hydroxyhexylidene)bisphosphonate 6-AMINO-1-HYDROXYHEXYLIDENE BISPHOSPHONIC ACID 6-Amino-1-hydroxyhexylidene bisphosphonic acid,Neridronic acid,Nerixia 6-amino-1-hydroxyhexane-1,1-diphosphonate (6-amino-1-hydroxy-1-phosphonohexyl)phosphonic acid (6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid) NERIDRONATE Neridronic acid |
| Description | Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Paget’s disease of bone (PDB). Neridronate is effective also in other skeletal diseases such as osteoporosis, algodystrophy, hypercalcemia of malignancy, and bone metastases[1][2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 600.1±65.0 °C at 760 mmHg |
| Melting Point | 245° |
| Molecular Formula | C6H17NO7P2 |
| Molecular Weight | 277.149 |
| Flash Point | 316.7±34.3 °C |
| Exact Mass | 277.048035 |
| PSA | 180.93000 |
| LogP | -3.36 |
| Vapour Pressure | 0.0±3.9 mmHg at 25°C |
| Index of Refraction | 1.569 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: 8 mg/mL, soluble |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
|
~89%
79778-41-9 |
| Literature: Alanne, Aino-Liisa; Ylisirnioe, Markku; Turhanen, Petri; Peraeniemi, Sirpa; Vepsaelaeinen, Jouko; Hyvoenen, Helena; Lahtinen, Manu; Kolehmainen, Erkki Molecules, 2012 , vol. 17, # 9 p. 10928 - 10945,18 |
|
~88%
79778-41-9 |
| Literature: Guenin, Erwann; Monteil, Maelle; Bouchemal, Nadia; Prange, Thierry; Lecouvey, Marc European Journal of Organic Chemistry, 2007 , # 20 p. 3380 - 3391 |
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79778-41-9 |
| Literature: US4407761 A1, ; |
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~%
79778-41-9 |
| Literature: European Journal of Organic Chemistry, , # 20 p. 3380 - 3391 |
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~%
79778-41-9 |
| Literature: European Journal of Organic Chemistry, , # 20 p. 3380 - 3391 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |