Shanghai Nianxing Industrial Co., Ltd
China
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Conessine
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DC Chemicals Limited
China
Product Name: Conessine
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546-06-5

546-06-5 structure

546-06-5 structure

Name: Conessine
Chemical Name: conessine
CAS Number: 546-06-5
Molecular Formula: C₂₄H₄₀N₂
Molecular Weight: 356.588
Catalog: Biochemical Plant extracts
Create Date: 2018-04-18 08:00:00
Modify Date: 2024-01-02 12:32:51
Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].

Name	conessine
Synonyms	3β-(Dimethylamino)con-5-enine 3-β-(Dimethylamino)con-5-enine CONESSIN Conessine Con-5-enin-3-amine, N,N-dimethyl-, (3β)- (3S,3aS,5aS,5bR,9S,11aR,11bS,13aR)-N,N,2,3,11a-Pentamethyl-2,3,3a,4,5,5a,5b,6,8,9,10,11,11a,11b,12,13-hexadecahydro-1H-naphtho[2',1':4,5]indeno[1,7a-c]pyrrol-9-amine Konessin ROGUESSINE Conessine,N,N-Dimethyl-con-5-enin-3-amine (3β)-N,N-Dimethylcon-5-enin-3-amine ROQUESSINE Wrightine NERVINE 3β-(Dimethylamino)con-5-ene (3b)-N,N-Dimethylcon-5-enin-3-amine 3b-(Dimethylamino)con-5-enine Con-5-enine, 3β- (dimethylamino)- NERIINE Con-5-enine, 3-β-(dimethylamino)- 1-Deazaadenosine 5-CONENIN-3BETA-DIMETHYLAMINE

Description	Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H3 Receptor:5.4 nM (Ki) rat H3 receptor:25 nM (Ki) Guinea pig H3 Receptor:6.0 nM (Ki) Dog H3 Receptor:5.7 nM (Ki)
References	[1]. Santora VJ, et al. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett. 2008;18(4):1490-1494. [2]. Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009.

Density	1.1±0.1 g/cm3
Boiling Point	450.4±45.0 °C at 760 mmHg
Melting Point	126-127ºC
Molecular Formula	C₂₄H₄₀N₂
Molecular Weight	356.588
Flash Point	199.6±16.5 °C
Exact Mass	356.319153
PSA	6.48000
LogP	5.71
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.564

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GK7621000

CHEMICAL NAME :: Con-5-enine, 3-beta-(dimethylamino)-

CAS REGISTRY NUMBER :: 546-06-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C24-H40-N2

MOLECULAR WEIGHT :: 356.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 208 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,373,1936

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 138 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,373,1936

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
RTECS	GK7621000

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