Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Conessine
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Conessine
Price: ￥738.0/10mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Conessine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Conessine
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

546-06-5

546-06-5 structure

546-06-5 structure

Name: Conessine
Chemical Name: conessine
CAS Number: 546-06-5
Molecular Formula: C₂₄H₄₀N₂
Molecular Weight: 356.588
Catalog: Biochemical Plant extracts
Create Date: 2018-04-18 08:00:00
Modify Date: 2025-08-26 14:56:20
Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].

Name	conessine
Synonyms	3β-(Dimethylamino)con-5-enine 3-β-(Dimethylamino)con-5-enine CONESSIN Conessine Con-5-enin-3-amine, N,N-dimethyl-, (3β)- (3S,3aS,5aS,5bR,9S,11aR,11bS,13aR)-N,N,2,3,11a-Pentamethyl-2,3,3a,4,5,5a,5b,6,8,9,10,11,11a,11b,12,13-hexadecahydro-1H-naphtho[2',1':4,5]indeno[1,7a-c]pyrrol-9-amine Konessin ROGUESSINE Conessine,N,N-Dimethyl-con-5-enin-3-amine (3β)-N,N-Dimethylcon-5-enin-3-amine ROQUESSINE Wrightine NERVINE 3β-(Dimethylamino)con-5-ene (3b)-N,N-Dimethylcon-5-enin-3-amine 3b-(Dimethylamino)con-5-enine Con-5-enine, 3β- (dimethylamino)- NERIINE Con-5-enine, 3-β-(dimethylamino)- 1-Deazaadenosine 5-CONENIN-3BETA-DIMETHYLAMINE

Description	Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H3 Receptor:5.4 nM (Ki) rat H3 receptor:25 nM (Ki) Guinea pig H3 Receptor:6.0 nM (Ki) Dog H3 Receptor:5.7 nM (Ki)
References	[1]. Santora VJ, et al. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett. 2008;18(4):1490-1494. [2]. Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009.

Density	1.1±0.1 g/cm3
Boiling Point	450.4±45.0 °C at 760 mmHg
Melting Point	126-127ºC
Molecular Formula	C₂₄H₄₀N₂
Molecular Weight	356.588
Flash Point	199.6±16.5 °C
Exact Mass	356.319153
PSA	6.48000
LogP	5.71
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.564

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GK7621000

CHEMICAL NAME :: Con-5-enine, 3-beta-(dimethylamino)-

CAS REGISTRY NUMBER :: 546-06-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C24-H40-N2

MOLECULAR WEIGHT :: 356.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 208 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,373,1936

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 138 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,373,1936

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
RTECS	GK7621000

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.