Conessine

Modify Date: 2024-01-02 12:32:51

Conessine Structure
Conessine structure
Common Name Conessine
CAS Number 546-06-5 Molecular Weight 356.588
Density 1.1±0.1 g/cm3 Boiling Point 450.4±45.0 °C at 760 mmHg
Molecular Formula C24H40N2 Melting Point 126-127ºC
MSDS Chinese USA Flash Point 199.6±16.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Conessine


Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].

 Names

Name conessine
Synonym More Synonyms

 Conessine Biological Activity

Description Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].
Related Catalog
Target

H3 Receptor:5.4 nM (Ki)

rat H3 receptor:25 nM (Ki)

Guinea pig H3 Receptor:6.0 nM (Ki)

Dog H3 Receptor:5.7 nM (Ki)

References

[1]. Santora VJ, et al. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett. 2008;18(4):1490-1494.

[2]. Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 450.4±45.0 °C at 760 mmHg
Melting Point 126-127ºC
Molecular Formula C24H40N2
Molecular Weight 356.588
Flash Point 199.6±16.5 °C
Exact Mass 356.319153
PSA 6.48000
LogP 5.71
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.564

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GK7621000
CHEMICAL NAME :
Con-5-enine, 3-beta-(dimethylamino)-
CAS REGISTRY NUMBER :
546-06-5
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C24-H40-N2
MOLECULAR WEIGHT :
356.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
208 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,373,1936
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
138 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,373,1936

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
RTECS GK7621000

 Articles23

More Articles
[New orientation and new therapeutic weapons in the therapy of intestinal amebiasis].

Minerva Med. 43(59-60) , 129-33, (1952)

Highly enantioselective construction of fused pyrrolidine systems that contain a quaternary stereocenter: concise formal synthesis of (+)-conessine.

Angew. Chem. Int. Ed. Engl. 43(19) , 2543-6, (2004)

High-performance thin layer chromatography method for estimation of conessine in herbal extract and pharmaceutical dosage formulations.

J. Pharm. Biomed. Anal. 46(2) , 391-4, (2008)

A new, simple, sensitive, precise and robust high-performance thin layer chromatographic (HPTLC) method was developed for the estimation of conessine in herbal extracts and pharmaceutical dosage forms...

 Synonyms

3β-(Dimethylamino)con-5-enine
3-β-(Dimethylamino)con-5-enine
CONESSIN
Conessine
Con-5-enin-3-amine, N,N-dimethyl-, (3β)-
(3S,3aS,5aS,5bR,9S,11aR,11bS,13aR)-N,N,2,3,11a-Pentamethyl-2,3,3a,4,5,5a,5b,6,8,9,10,11,11a,11b,12,13-hexadecahydro-1H-naphtho[2',1':4,5]indeno[1,7a-c]pyrrol-9-amine
Konessin
ROGUESSINE
Conessine,N,N-Dimethyl-con-5-enin-3-amine
(3β)-N,N-Dimethylcon-5-enin-3-amine
ROQUESSINE
Wrightine
NERVINE
3β-(Dimethylamino)con-5-ene
(3b)-N,N-Dimethylcon-5-enin-3-amine
3b-(Dimethylamino)con-5-enine
Con-5-enine, 3β- (dimethylamino)-
NERIINE
Con-5-enine, 3-β-(dimethylamino)-
1-Deazaadenosine
5-CONENIN-3BETA-DIMETHYLAMINE
Top Suppliers:I want be here




Get all suppliers and price by the below link:

Conessine suppliers

Conessine price