Nanjing Peptide Biotech Ltd
China
Product Name: Eledoisin
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Zhejiang Hangyu API Co., Ltd
China
Product Name: Eledoisin
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

69-25-0

69-25-0 structure

69-25-0 structure

Name: Eledoisin acetate salt
Chemical Name: Eledoisin
CAS Number: 69-25-0
Molecular Formula: C₅₄H₈₅N₁₃O₁₅S
Molecular Weight: 1188.396
Catalog: Biochemical Peptide
Create Date: 2018-05-16 08:00:00
Modify Date: 2024-01-02 11:24:48
Eledoisin is a specific agonist of NK2 and NK3 receptors. Sequence: {Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2.

Name	Eledoisin
Synonyms	5-Oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-α-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-L-methioninamide PGLU-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2 ELEDOSIN GLP-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2 PYR-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2 eledonepeptide 5-Oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-L-methioninamide Eledone peptide L-methioninamide, 5-oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-α-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl- pEPSKDAFIGLM-NH2 FI 6225 TF/Ocoa 5-Oxo-L-Pro-L-Pro-L-Ser-L-Lys-L-Asp-L-Ala-L-Phe-L-Ile-Gly-L-Leu-L-Met-NH2 PYR-PSKDAFIGLM-NH2 eledoisin Eledoisin Acetate

Description	Eledoisin is a specific agonist of NK2 and NK3 receptors. Sequence: {Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Peptides
Target	NK2 and NK3 receptors[1].
In Vitro	Eledoisin increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively[1].
In Vivo	Eledoisin (0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice[2].
References	[1]. Lippe C, et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides. 2004 Nov;25(11):1971-5. [2]. Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322.

Density	1.3±0.1 g/cm3
Boiling Point	1618.1±65.0 °C at 760 mmHg
Molecular Formula	C₅₄H₈₅N₁₃O₁₅S
Molecular Weight	1188.396
Flash Point	932.4±34.3 °C
Exact Mass	1187.600830
PSA	463.25000
LogP	-1.36
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.569
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JX8688000

CHEMICAL NAME :: Eledoisin

CAS REGISTRY NUMBER :: 69-25-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C54-H85-N13-O15-S

MOLECULAR WEIGHT :: 1188.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Cardiac - other changes Vascular - BP lowering not characterized in autonomic section

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 18,58,1962

WGK Germany	3
RTECS	JX8688000