200959-47-3

200959-47-3 structure

Name: AC-ARG-TYR-TYR-ARG-TRP-LYS-NH2
Chemical Name: Ac-RYYRWK-NH2
CAS Number: 200959-47-3
Molecular Formula: C₄₉H₆₉N₁₅O₉
Molecular Weight: 1012.17000
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2017-06-16 05:24:52
Modify Date: 2024-01-16 14:30:45
Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1].

Name	Ac-RYYRWK-NH2
Synonyms	AC-ARG-TYR-TYR-ARG-TRP-LYS-NH2 Ac-RYYRWK amide

Description	Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	Kd: 0.071 nM (ORL1 in rat cortical membranes)[1]
References	[1]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41. [2]. M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.