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52727-57-8

52727-57-8 structure
52727-57-8 structure
  • Name: Methyl 2-amino-5-bromobenzoate
  • Chemical Name: methyl 2-amino-5-bromobenzoate
  • CAS Number: 52727-57-8
  • Molecular Formula: C8H8BrNO2
  • Molecular Weight: 230.06
  • Catalog: Chemical reagent Organic reagent Ester Methyl ester compound
  • Create Date: 2018-04-25 08:00:00
  • Modify Date: 2024-01-02 17:29:55
  • Methyl 2-amino-5-bromobenzoate (compound 8/12) can be used for synthesis of 2-benzamidobenzoic acids, which are known FabH inhibitors. The derivates also inhibit PqsD, the pqs quorum sensing (QS) system of Pseudomonas aeruginosa, involving the production of a number of virulence factors and biofilm formation[1].

Name methyl 2-amino-5-bromobenzoate
Synonyms estere metilico dell'acido 5-bromoantranilico
Methyl 2-amino-5-bromobenzoate
Benzoic acid, 2-amino-5-bromo-, methyl ester
Benzoic acid,2-amino-5-bromo-,methyl ester,hydrochloride
MFCD00144761
Methyl-2-amino-5-brombenzolcarboxylat
2-Amino-5-bromobenzoic Acid Methyl Ester
methyl 2-amino-5-bromo-benzoate
5-Bromoanthranilic Acid Methyl Ester
Methyl 5-Bromoanthranilate
5-bromo-2-amino-benzoic acid methyl ester
METHYL2-AMINO-5-BROMOBENZOATE
Description Methyl 2-amino-5-bromobenzoate (compound 8/12) can be used for synthesis of 2-benzamidobenzoic acids, which are known FabH inhibitors. The derivates also inhibit PqsD, the pqs quorum sensing (QS) system of Pseudomonas aeruginosa, involving the production of a number of virulence factors and biofilm formation[1].
Related Catalog
References

[1]. Weidel E, et al. Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking. J Med Chem. 2013 Aug 8;56(15):6146-55.  

Density 1.6±0.1 g/cm3
Boiling Point 286.3±20.0 °C at 760 mmHg
Melting Point 72-74 °C(lit.)
Molecular Formula C8H8BrNO2
Molecular Weight 230.06
Flash Point 126.9±21.8 °C
Exact Mass 228.973831
PSA 52.32000
LogP 3.06
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.601
Storage condition Room temperature.
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2922499990
HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%