374750-30-8

374750-30-8 structure

Name: 2'-C-Methylguanosine
Chemical Name: 2-amino-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3H-purin-6-one
CAS Number: 374750-30-8
Molecular Formula: C₁₁H₁₅N₅O₅
Molecular Weight: 297.27
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-08-17 22:17:27
Modify Date: 2025-08-31 18:16:50
2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

Name	2-amino-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3H-purin-6-one
Synonyms	2`-C-Beta-Methyl Guanosine 2'-METHYLGUANOSINE 2'-C-Methylguanosine Guanosine, 2'-C-methyl- 2-amino-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purin-6-ol 9H-purin-6-ol, 2-amino-9-(2-C-methyl-β-D-ribofuranosyl)-

Description	2'-C-Methylguanosine (2'-C-beta-Methylguanosine) is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

RIDADR	NONH for all modes of transport