13408-56-5

13408-56-5 structure

Name: ponasterone A
Chemical Name: ponasterone A
CAS Number: 13408-56-5
Molecular Formula: C₂₇H₄₄O₆
Molecular Weight: 464.635
Catalog: Natural product Steroidal compound
Create Date: 2018-08-21 13:02:39
Modify Date: 2026-06-30 14:08:54
Ponasterone A (25-Deoxyecdysterone), an ecdysteroid, has strong affinity for the ecdysone receptor. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly[1][2].

Name	ponasterone A
Synonyms	25-DEOXY-20-HYDROXYECDYSONE (20R,22R)-2β,3β,14α,20β,22α-Pentahydroxy-5β-cholesta-7-ene-6-one 25-Deoxyecdysterone Cholest-7-en-6-one, 2,3,14,20,22-pentahydroxy-, (2β,3β,5β,22R) (2b,3b,5b,22R)-2,3,14,20,22-Pentahydroxycholest-7-en-6-one PONASTERONE A (2S,3R,5R,9R,10R,13R,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methylhtan-2-yl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one 25-Deoxy-20-hydroxyecdysone, 25-Deoxyecdysterone, 2β,3β,14α,20R,22R-Pentahydroxy-5β-cholest-7-en-6-one (2β,3β,5β,22R)-2,3,14,20,22-Pentahydroxycholest-7-en-6-one gene,ecdysone,ecdysteroid,25-Deoxyecdysterone,expression,inhibit,Ponasterone A,Inhibitor ponesterone A 2β,3β,14α,20r,22r-pentahydroxy-5β-cholest-7-en-6-one 2B,3B,14A,20R,22R-PENTAHYDROXY-5B-CHOLEST-7-EN-6-ONE 25-Deoxy-20-hydroxyecdysone MFCD00272144 (20R,22R)-2β,3β,14,20,22-Pentahydroxy-5β-cholesta-7-ene-6-one 2BETA, 3BETA, 14ALPHA, 20R,22R-PENTAHYDROXY-5BETA-CHOLEST-7-EN-6-ONE (2S,3R,5R,9R,10R,13R,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one Ponasterone A, >= 25-DEOXYECDYSTERONE Ponasterone A, Ecdysone analog

Description	Ponasterone A (25-Deoxyecdysterone), an ecdysteroid, has strong affinity for the ecdysone receptor. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	ecdysone receptor[2]
In Vitro	Ponasterone A (1 nM-100 μM) shows significant gene induction activity in CV-1 cells[2].
In Vivo	Ponasterone A (3-10 mg; i.p.) produces robust inductions of gene expression in transactivator and reporter mice[2].
References	[1]. Hansen KØ, et, al. Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum. Molecules. 2018 Jun 19;23(6):1481. [2]. Gu Y,et, al. Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. J Biol Chem. 2000 Jun 16;275(24):17917-20.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3