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102029-74-3

102029-74-3 structure
102029-74-3 structure
  • Name: β-Casomorphin (human)
  • Chemical Name: β-Casomorphin
  • CAS Number: 102029-74-3
  • Molecular Formula: C44H61N7O11
  • Molecular Weight: 863.99500
  • Catalog: Peptides
  • Create Date: 2018-05-02 08:00:00
  • Modify Date: 2025-08-21 17:31:10
  • β-Casomorphin, human is an opioid peptide, acts as an agonist of opioid receptor.
Name β-Casomorphin
Synonyms 2-[[1-[2-[[2-[[2-[[1-[2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid
β-Casomorphin (1-7), human
β-Casomorphin, human
Description β-Casomorphin, human is an opioid peptide, acts as an agonist of opioid receptor.
Related Catalog
Target

Opioid receptor[2]

In Vitro β-Casomorphin, human (TyrPro-Phe-Val-Glu-Pro-Ile) is also called human B-casein-(51-57), with the sequenceequivalent to bovine B-casein-(60-66) (Tyr-ProPhe-Pro-G]y-Pro-Ile or B-casomorphin-7)[1]. β-Casomorphin, human (100 μM) increases the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC in rat DHE cells, also elevates increased MUC5AC mRNA levels[2].
Cell Assay To study the effect of β-Casomorphin, human and DAMGO, cells are seeded in 12-well culture plates. Experiments are performed 3 (DHE cells) or 21 days (HT29-MTX cells) after confluency. Twenty-four hours before the studies, the culture medium is replaced by serum-free medium to starve the cells from serum and to eliminate any interference from extraneous proteins or hormones. The experimental protocol is then the following: the serum-free medium is removed, and the monolayer cultures of DHE or HT29-MTX are washed twice with PBS (37°C). Serum-free medium with or without β-Casomorphin, human or DAMGO is added to the cells and incubated at 37°C for 30 min to 24 h in a humidified atmosphere. μ-Opioid receptor blockade is performed by preincubating the cells with cyprodime for 30 min before agonist addition. The supernatants are then collected, frozen, and stored at 20°C. Cells are processed with trypsin. The cell numbers per well are determined, and total RNA is isolated. All experiments are performed at least three times in triplicate[2].
References

[1]. Brantl V. Novel opioid peptides derived from human beta-casein: human beta-casomorphins. Eur J Pharmacol. 1984 Oct 30;106(1):213-4.

[2]. Zoghbi S, et al. beta-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a mu-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13.
Density 1.299 g/cm3
Boiling Point 1239.2ºC at 760 mmHg
Molecular Formula C44H61N7O11
Molecular Weight 863.99500
Flash Point 703.2ºC
Exact Mass 863.44300
PSA 277.87000
LogP 3.21710
Storage condition 2-8℃
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
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