58523-30-1
58523-30-1 structure
- Name: pseurotin A
- Chemical Name: pseurotin A
- CAS Number: 58523-30-1
- Molecular Formula: C22H25NO8
- Molecular Weight: 431.436
- Catalog: Natural product Alkaloid
- Create Date: 2017-11-28 22:20:01
- Modify Date: 2024-01-04 09:24:10
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Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50=3.6 μM). Antitumor activity[1][2][3].
| Name | pseurotin A |
|---|---|
| Synonyms |
(5S,8S,9R)-8-benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxyhex-3-en-1-yl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione
(5S,8S,9R)-8-Benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexenyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione pseurotin A PB-1 (5S,8S,9R)-8-Benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexen-1-yl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione pseurotin-A pseurotin 1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 8-benzoyl-2-[(1S,2S,3Z)-1,2-dihydroxy-3-hexen-1-yl]-9-hydroxy-8-methoxy-3-methyl-, (5S,8S,9R)- (5S)-8c-benzoyl-9t-hydroxy-2-((1S,2S)-1,2-dihydroxy-hex-3c-enyl)-8t-methoxy-3-methyl-(5rO)-1-oxa-7-aza-spiro[4.4]non-2-ene-4,6-dione |
| Description | Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50=3.6 μM). Antitumor activity[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Pseurotin A inhibits the expression of PCSK9 in HepG2 cells, with an IC50 value of 1.2 μM. Pseurotin A (25-100 μM; 72 hours) significantly suppressed the PCSK9 level in a dose dependent manner in BT-474 and T47D BC cell lines. Pseurotin A (25-100 μM; 72 hours) significantly increases LDLR level in a dose dependent manner[3]. Pseurotin A (40-200 μM; 24-72 hours) shows anti-proliferative activity in the hormone-dependent BC cells[3]. Cell Viability Assay[3] Cell Line: BT-474 cells, T47D cells Concentration: 40-200 μM Incubation Time: 24-72 hours Result: Showed weak but time and dose-dependent inhibition of the growth of BT-474 and T47D BC cells, with gradual decrease of the IC50 values over time (260.83-93.64 μM and 267.84-113.08 μM, respectively). |
| In Vivo | Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity[3]. Animal Model: HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode)[1] Dosage: 10 mg/kg Administration: P.o.; 7X/week, 30 days Result: Significantly suppressed the growth of BT474 tumors. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 751.5±60.0 °C at 760 mmHg |
| Melting Point | 126.0-126.9℃ |
| Molecular Formula | C22H25NO8 |
| Molecular Weight | 431.436 |
| Flash Point | 408.3±32.9 °C |
| Exact Mass | 431.158020 |
| PSA | 142.39000 |
| LogP | 3.23 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.626 |
| Hazard Codes | Xi |
|---|
| Precursor 2 | |
|---|---|
| DownStream 0 | |
