Shanghai Nianxing Industrial Co., Ltd
China
Product Name: McN3716
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Oxiranecarboxylicacid, 2-tetradecyl-, methyl ester
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

69207-52-9

69207-52-9 structure

69207-52-9 structure

Name: 2-Tetradecyl-2-oxiranecarboxylic acid methyl ester
Chemical Name: Methyl palmoxirate
CAS Number: 69207-52-9
Molecular Formula: C₁₈H₃₄O₃
Molecular Weight: 298.46100
Catalog: Research Areas Metabolic Disease
Create Date: 2016-05-19 00:54:37
Modify Date: 2024-01-30 20:33:14
McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor.

Name	Methyl palmoxirate
Synonyms	methyl 2-tetradecyloxirane-2-carboxylate 2-Tetradecyloxiranecarboxylic acid methyl ester methyl 2-tetradecylglycidate MCN-3716 Methyl parmoxirate methyl 2-tetradecyloxiranecarboxylate 2-Tetradecyloxirane-2-carboxylic acid methyl ester ethyl palmoxirate 2-Tetradecyl-2-oxiranecarboxylic acid methyl ester McN3716

Description	McN3716 is a carnitine palmitoyltransferase I (CPT-1) inhibitor.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	Carnitine palmitoyltransferase I (CPT-1)[1]
In Vivo	Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF1α, a byproduct of PGI2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle[1].
Animal Admin	Rats[1] Male Sprague Dawley rats are used. The rats receive ad libitum access to standard chow and water. At 15 weeks of age, six rats were subjected to either high-energy, head-focused microwave irradiation or CO2 asphyxiation. A separate group of 11 rats were implanted with a tail vein catheter (intravenous catheter 24 gauge/0.75 inch) and received either an intravenous injection of vehicle or 10 mg/kg of McN3716. Fifteen minutes after injection, rats were rapidly euthanized by high-energy, head-focused microwave irradiation (13.5 kW for 1.6 seconds) to avert ischemia for accurate quantification of in vivo basal levels of nonenzymatic auto-oxidative PUFA metabolites and enzymatically derived metabolites. Previously, we reported that this method reduced β-oxidation of fatty acid by 23% to 74%. McN3716 (Methyl palmoxirate, MEP) readily crosses the blood–brain barrier with a plasma half-life of 0.6 minute in the rat. The brain was excised and stored at -80°C for lipidomics profiling.
References	[1]. Chen CT, et al. Inhibiting mitochondrial β-oxidation selectively reduces levels of nonenzymatic oxidative polyunsaturated fatty acid metabolites in the brain. J Cereb Blood Flow Metab. 2014 Mar;34(3):376-9.

Density	0.944g/cm3
Boiling Point	361.4ºC at 760 mmHg
Melting Point	44-46 ºC
Molecular Formula	C₁₈H₃₄O₃
Molecular Weight	298.46100
Flash Point	150.9ºC
Exact Mass	298.25100
PSA	38.83000
LogP	5.01960
Index of Refraction	1.46
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RR0425000

CHEMICAL NAME :: 2-Oxiranecarboxylic acid, 2-tetradecyl-, methyl ester

CAS REGISTRY NUMBER :: 69207-52-9

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H34-O3

MOLECULAR WEIGHT :: 298.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 145 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,47A,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 29 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,47A,1987

73472-08-9 structure

73472-08-9

~73%

69207-52-9 structure

69207-52-9

Literature: Basavaiah, Deevi; Kumaragurubaran, Nagaswamy Tetrahedron Letters, 2001 , vol. 42, # 3 p. 477 - 479

112-71-0 structure

112-71-0

~%

69207-52-9 structure

69207-52-9

Literature: Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190

6818-50-4 structure

6818-50-4

~%

69207-52-9 structure

69207-52-9

Literature: Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190

41240-57-7 structure

41240-57-7

~%

69207-52-9 structure

69207-52-9

Literature: Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190

104157-07-5 structure

104157-07-5

~%

69207-52-9 structure

69207-52-9

Literature: Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190

Precursor 5
73472-08-9 112-71-0 6818-50-4 41240-57-7
104157-07-5
DownStream 0