10212-20-1

10212-20-1 structure

Name: 2'-Deoxy-2'-fluorocytidine
Chemical Name: 2'-Deoxy-2'-fluorocytidine
CAS Number: 10212-20-1
Molecular Formula: C₉H₁₂FN₃O₄
Molecular Weight: 245.208
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-08-27 05:13:52
Modify Date: 2024-01-02 21:30:20
2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication[1].

Name	2'-Deoxy-2'-fluorocytidine
Synonyms	2'-Deoxy-2'-fluorocytidine 2'-FdC MFCD00057445 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one 2'-Deoxy-2'-fluoro-D-cytidine 2'-FLUORO-D-CYTIDINE 2'-FC Cytidine, 2'-deoxy-2'-fluoro- 2`-Deoxy-2`-fluoro Cytidine RO-8013 2′-Fluoro-2′-deoxycytidine 2'-Fluoro-2'-deoxycytidine

Description	2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
In Vitro	2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells[1].
References	[1]. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%