2'-Deoxy-2'-fluorocytidine

Modify Date: 2024-01-02 21:30:20

2'-Deoxy-2'-fluorocytidine Structure
2'-Deoxy-2'-fluorocytidine structure
Common Name 2'-Deoxy-2'-fluorocytidine
CAS Number 10212-20-1 Molecular Weight 245.208
Density 1.8±0.1 g/cm3 Boiling Point 500.1±60.0 °C at 760 mmHg
Molecular Formula C9H12FN3O4 Melting Point 167ºC
MSDS N/A Flash Point 256.2±32.9 °C

 Use of 2'-Deoxy-2'-fluorocytidine


2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication[1].

 Names

Name 2'-Deoxy-2'-fluorocytidine
Synonym More Synonyms

 2'-Deoxy-2'-fluorocytidine Biological Activity

Description 2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication[1].
Related Catalog
In Vitro 2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells[1].
References

[1]. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 500.1±60.0 °C at 760 mmHg
Melting Point 167ºC
Molecular Formula C9H12FN3O4
Molecular Weight 245.208
Flash Point 256.2±32.9 °C
Exact Mass 245.081177
PSA 110.60000
LogP -1.26
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.697
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2'-Deoxy-2'-fluorocytidine
2'-FdC
MFCD00057445
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
2'-Deoxy-2'-fluoro-D-cytidine
2'-FLUORO-D-CYTIDINE
2'-FC
Cytidine, 2'-deoxy-2'-fluoro-
2`-Deoxy-2`-fluoro Cytidine
RO-8013
2′-Fluoro-2′-deoxycytidine
2'-Fluoro-2'-deoxycytidine
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