2784-50-1

2784-50-1 structure

Name: L-Glutamic acid-d5
Chemical Name: (2S)-2-amino-2,3,3,4,4-pentadeuteriopentanedioic acid
CAS Number: 2784-50-1
Molecular Formula: C₅H₄D₅NO₄
Molecular Weight: 152.160
Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative
Create Date: 2018-03-15 08:00:00
Modify Date: 2024-01-07 20:08:49
L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

Name	(2S)-2-amino-2,3,3,4,4-pentadeuteriopentanedioic acid
Synonyms	L-(2,3,3,4,4-H)Glutamic acid glutamic acid-d5 2,3,3,4,4-pentadeuterio-L-glutamic acid Glusate-d5 L-Glutamic-2,3,3,4,4-d acid L-glutamic-2,3,3,4,4-d5 acid Glutacid-d5 Glutamicol-d5 L-\|A-Aminoglutaric Acid-d5 Glutaminol-d5 Glutaton-d5 Glutamidex-d5

Description	L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Apoptosis >> Ferroptosis Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

WGK Germany	3