Name | l-ap5 |
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Synonyms |
D(-)-APV
L-AP5 [3H]-D(-)-2-Amino-5-phosphonopentanoic acid D-2-Amino-5-phosphonovaleric acid D-2-Amino-5-phosphopentanoic acid L-Norvaline, 5-phosphono- 5-Phosphono-D-norvaline D-Norvaline,5-phosphono L-(+)-2-Amino-5-phosphonopentanoic acid Quinolinic acid D-AP5 D(-)-2-Amino-5-phosphonopentanoic acid |
Description | L-AP5 (L-APV; L-2-Amino-5-phosphonovaleric acid) is an NMDA antagonist and is the isomer of D-AP5 (HY-100714A).L-AP5 shows a relatively weak amino acid and synaptic blocking activity[1]. |
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Related Catalog | |
Target |
NMDA Receptor |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 482.1±55.0 °C at 760 mmHg |
Molecular Formula | C5H12NO5P |
Molecular Weight | 197.13 |
Flash Point | 245.4±31.5 °C |
Exact Mass | 197.045303 |
PSA | 130.66000 |
LogP | -2.32 |
Vapour Pressure | 0.0±2.6 mmHg at 25°C |
Index of Refraction | 1.536 |
Synonym:L-5-Phosphononorvaline; L-2-Amino-5-phosphonopentanoic acid; L-AP-5; 5-Phosphono-L-norvaline; L-2-Amino-5-phosphonopentanoic acid; L-2-Amino-5-phosphonovaleric acid Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be absorbed through the skin. Ingestion: May cause irritation of the digestive tract. Inhalation: May cause respiratory tract irritation. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustion generates toxic fumes. Use water spray to keep fire-exposed containers cool. Extinguishing Media: Use water spray, dry chemical, or carbon dioxide. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 79055-67-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: white Odor: No data pH: Not available. Vapor Pressure: Negligible Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 100 - 110 deg C Autoignition Temperature: Not available. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C5H12NO5P Molecular Weight: 197.13 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Strong oxidizers. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, oxides of phosphorus, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 79055-67-7 unlisted. LD50/LC50: Not available. Carcinogenicity: L-(+)-2-Amino-5-phosphonovaleric acid - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: IMO Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: RID/ADR Shipping Name: Not regulated. Hazard Class: UN Number: Packing group: Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 79055-67-7: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 79055-67-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 79055-67-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |