1262406-08-5

1262406-08-5 structure

Name: p38α inhibitor 4
Chemical Name: 4-(Trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H- pyrazolo[3,4-b]pyridin-6-one
CAS Number: 1262406-08-5
Molecular Formula: C₁₄H₇F₆N₃O
Molecular Weight: 347.22
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2017-04-02 12:23:26
Modify Date: 2023-09-16 11:13:53
p38α inhibitor 4 (compound 10) is a selective and allosteric p38α inhibitor with an IC50 value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ[1].

Name	4-(Trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H- pyrazolo[3,4-b]pyridin-6-one

Description	p38α inhibitor 4 (compound 10) is a selective and allosteric p38α inhibitor with an IC50 value of 1.2 μM. p38α inhibitor 4 exhibits no activity against p38β, p38γ, and p38δ[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Target	p38α:1.2 μM (IC50)
References	[1]. ACS Chem. Biol., Article ASAPDOI: 10.1021/cb1002619Publication Date (Web): November 23, 2010 [2]. Kenneth M Comess, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44.