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20298-86-6

20298-86-6 structure
20298-86-6 structure
  • Name: phycocyanobilin
  • Chemical Name: (3E)-phycocyanobilin
  • CAS Number: 20298-86-6
  • Molecular Formula: C33H38N4O6
  • Molecular Weight: 586.67800
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-07-04 11:58:42
  • Modify Date: 2024-01-03 14:24:19
  • Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease[1][2][3].

Name (3E)-phycocyanobilin
Synonyms 3-[(2Z,5E)-2-[[3-(2-carboxyethyl)-5-[(Z)-[(3E,4R)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-2-yl]methylidene]-5-[(4-ethyl-3-methyl-5-oxopyrrol-2-yl)methylidene]-4-methylpyrrol-3-yl]propanoic acid
phycocyanobilin
3,3'-(18-ethyl-3-ethylidene-2,7,13,17-tetramethyl-1,19-dioxo-1,2,3,19,22,24-hexahydro-21H-biline-8,12-diyl)-bis-propionic acid
Phycobilin
21H-Biline-8,12-dipropanoic acid,18-ethyl-3-ethylidene-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-,(2R,3E)
Description Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease[1][2][3].
Related Catalog
In Vitro Phycocyanobilin (100 μM; 0-250 min) 抑制亚油酸甲酯的过氧化,并产生较长的诱导期[1]。 Phycocyanobilin (1 mM; 0-300 min) 抑制脂质体的氧化[1]。
In Vivo Phycocyanobilin (15 mg/kg; p.o.; in diet for 2 weeks) 在 2 型糖尿病小鼠中显示抗氧化作用[3]。 Animal Model: Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes[3] Dosage: 15 mg/kg Administration: In diet for 2 weeks Result: Significantly decreased blood glucose levels. Normalized the increases in urinary 8-OHdG and 8-epi-PGF2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1.
References

[1]. Hirata T, et al. Antioxidant activities of phycocyanobilin prepared from Spirulina platensis. Journal of Applied Phycology, 2000, 12: 435-439.

[2]. Matamoros BP, et al. Nutraceutical and therapeutic potential of Phycocyanobilin for treating Alzheimer's disease. J Biosci. 2021;46:42.  

[3]. Zheng J, et al. Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R110-20.  

Density 1.31±0.1 g/cm3
Boiling Point 892.1±65.0 °C
Molecular Formula C33H38N4O6
Molecular Weight 586.67800
Exact Mass 586.27900
PSA 164.71000
LogP 3.12850
Hazard Codes Xi
HS Code 3203001990
HS Code 3203001990