165682-93-9
165682-93-9 structure
- Name: O4I2
- Chemical Name: ethyl 2-(4-chloroanilino)-1,3-thiazole-4-carboxylate
- CAS Number: 165682-93-9
- Molecular Formula: C12H11ClN2O2S
- Molecular Weight: 282.746
- Catalog: Signaling Pathways Stem Cell/Wnt Oct3/4
- Create Date: 2018-12-02 18:48:08
- Modify Date: 2024-01-02 21:46:33
-
O4I2 is a potent Oct3/4 inducer in various human cell lines including human fibroblasts.Target: Oct3/4O4I2 activates Oct3/4 in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts. O4I2 activates also other pluripotencyassociatedgenes such as Lin28 and Nanog in a drug-like manner. O4I2 shows high activity in enforcing Oct3/4 expression. O4I2 activates Oct3/4 on the transcriptional and translational level in human fibroblasts. O4I2 promotes the expression of pluripotency-associated genes as analyzed by qRT-PCR in human neonatal foreskin fibroblasts (HFFs). O4I2 markedly stimulates Oct3/4 even at 5 μM after 72 h treatment on the translational level.
| Name | ethyl 2-(4-chloroanilino)-1,3-thiazole-4-carboxylate |
|---|---|
| Synonyms |
Ethyl 2-[(4-chlorophenyl)amino]-1,3-thiazole-4-carboxylate
ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE 4-Thiazolecarboxylic acid, 2-[(4-chlorophenyl)amino]-, ethyl ester O4I2 |
| Description | O4I2 is a potent Oct3/4 inducer in various human cell lines including human fibroblasts.Target: Oct3/4O4I2 activates Oct3/4 in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts. O4I2 activates also other pluripotencyassociatedgenes such as Lin28 and Nanog in a drug-like manner. O4I2 shows high activity in enforcing Oct3/4 expression. O4I2 activates Oct3/4 on the transcriptional and translational level in human fibroblasts. O4I2 promotes the expression of pluripotency-associated genes as analyzed by qRT-PCR in human neonatal foreskin fibroblasts (HFFs). O4I2 markedly stimulates Oct3/4 even at 5 μM after 72 h treatment on the translational level. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 408.1±51.0 °C at 760 mmHg |
| Molecular Formula | C12H11ClN2O2S |
| Molecular Weight | 282.746 |
| Flash Point | 200.6±30.4 °C |
| Exact Mass | 282.022980 |
| PSA | 79.46000 |
| LogP | 3.83 |
| Appearance | light yellow solid |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.637 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2934100090 |
| HS Code | 2934100090 |
|---|---|
| Summary | 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |