75483-04-4
75483-04-4 structure
- Name: AI-1
- Chemical Name: ethyl 4-chloro-1-methyl-2-oxoquinoline-3-carboxylate
- CAS Number: 75483-04-4
- Molecular Formula: C13H12ClNO3
- Molecular Weight: 265.69200
- Create Date: 2017-06-08 21:33:01
- Modify Date: 2024-01-18 18:51:36
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Nrf2 acticatior AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM.
| Name | ethyl 4-chloro-1-methyl-2-oxoquinoline-3-carboxylate |
|---|---|
| Synonyms |
ARE inducer-1
3-Quinolinecarboxylic acid,1,2-dihydro-4-chloro-1-methyl-2-oxo-,ethyl ester ethyl 1-methyl-4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate antioxidant response element inducer-1 1-methyl-2-oxo-4-chloroquinoline-3-carboxylic acid ethyl ester 4-Chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ethyl ester 4-chloro-1-methyl-2-oxoquinoline-3-carboxylic acid ethyl ester ethyl 4-chloro-2-oxo-N-methyl-1,2-dihydroquinoline-3-carboxylate ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate |
| Density | 1.34g/cm3 |
|---|---|
| Boiling Point | 358.7ºC at 760 mmHg |
| Molecular Formula | C13H12ClNO3 |
| Molecular Weight | 265.69200 |
| Flash Point | 170.7ºC |
| Exact Mass | 265.05100 |
| PSA | 48.30000 |
| LogP | 2.36860 |
| Index of Refraction | 1.597 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| RIDADR | NONH for all modes of transport |
|
~87%
75483-04-4 |
| Literature: Carrer, Amandine; Brion, Jean-Daniel; Messaoudi, Samir; Alami, Mouad Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 2044 - 2054 |
|
~%
75483-04-4 |
| Literature: Ismaili, Lhassane; Refouvelet, Bernard; Robert, Jean Francois Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 3 p. 719 - 722 |
|
~%
75483-04-4 |
| Literature: Ismaili, Lhassane; Refouvelet, Bernard; Robert, Jean Francois Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 3 p. 719 - 722 |
|
~%
75483-04-4 |
| Literature: Carrer, Amandine; Brion, Jean-Daniel; Messaoudi, Samir; Alami, Mouad Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 2044 - 2054 |
