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108466-89-3

108466-89-3 structure
108466-89-3 structure
  • Name: Boc-NH-PEG2-CH2COOH
  • Chemical Name: 2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]acetic acid
  • CAS Number: 108466-89-3
  • Molecular Formula: C11H21NO6
  • Molecular Weight: 263.28800
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-12-09 01:42:00
  • Modify Date: 2024-01-03 07:45:06
  • Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name 2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]acetic acid
Synonyms 2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid
8-tert-Butyloxycarbonylamino-3,6-dioxaoctanoic Acid
AmbotzBAA1466
Boc-AEEA
2-[2-[2-(Boc-amino)ethoxy]ethoxy]acetic Acid
Description Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2020 Feb 1;187:111952.

Boiling Point 630.4°C
Melting Point 240°C
Molecular Formula C11H21NO6
Molecular Weight 263.28800
Exact Mass 263.13700
PSA 97.58000
LogP 0.83330
Storage condition 2-8°C
Hazard Codes Xi
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%