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110816-78-9

110816-78-9 structure
110816-78-9 structure
  • Name: KY-556
  • Chemical Name: ethyl 5-[2-[(2S)-2,6-diaminohexanoyl]oxy-3-(2-ethoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate,dihydrochloride
  • CAS Number: 110816-78-9
  • Molecular Formula: C33H38Cl2N2O12
  • Molecular Weight: 725.56700
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2017-04-12 23:08:56
  • Modify Date: 2024-01-10 15:54:54
  • KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases.
Name ethyl 5-[2-[(2S)-2,6-diaminohexanoyl]oxy-3-(2-ethoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate,dihydrochloride
Synonyms 2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride
ethyl 5-[2-[(2S)-2,6-diaminohexanoyl]oxy-3-(2-ethoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate dihydrochloride
diethyl L-lysylcromoglycate dihydrochloride
Cromoglicate lisetil hydrochloride (JAN)
1,3-Bis-(2-ethoxycarbonylchromon-5-yloxy)-2-(lysyloxy)propane
KY 556
L-Lysine,2-((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)-1-(((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)methyl)ethyl ester,dihydrochloride
KY-556
Description KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases.
Related Catalog
In Vivo The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1].
References

[1]. Nakamura S, et al. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8.
Boiling Point 789.7ºC at 760mmHg
Molecular Formula C33H38Cl2N2O12
Molecular Weight 725.56700
Flash Point 212.5ºC
Exact Mass 724.18000
PSA 209.82000
LogP 6.08330
Vapour Pressure 6.46E-25mmHg at 25°C
Storage condition 2-8℃

Chemsrc provides CAS#:110816-78-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 110816-78-9 | Chemsrc address: https://m.chemsrc.com/en/baike/1128812.html

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