110816-78-9
110816-78-9 structure
- Name: KY-556
- Chemical Name: ethyl 5-[2-[(2S)-2,6-diaminohexanoyl]oxy-3-(2-ethoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate,dihydrochloride
- CAS Number: 110816-78-9
- Molecular Formula: C33H38Cl2N2O12
- Molecular Weight: 725.56700
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2017-04-12 23:08:56
- Modify Date: 2024-01-10 15:54:54
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KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases.
| Name | ethyl 5-[2-[(2S)-2,6-diaminohexanoyl]oxy-3-(2-ethoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate,dihydrochloride |
|---|---|
| Synonyms |
2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride
ethyl 5-[2-[(2S)-2,6-diaminohexanoyl]oxy-3-(2-ethoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate dihydrochloride diethyl L-lysylcromoglycate dihydrochloride Cromoglicate lisetil hydrochloride (JAN) 1,3-Bis-(2-ethoxycarbonylchromon-5-yloxy)-2-(lysyloxy)propane KY 556 L-Lysine,2-((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)-1-(((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)methyl)ethyl ester,dihydrochloride KY-556 |
| Description | KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases. |
|---|---|
| Related Catalog | |
| In Vivo | The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1]. |
| References |
| Boiling Point | 789.7ºC at 760mmHg |
|---|---|
| Molecular Formula | C33H38Cl2N2O12 |
| Molecular Weight | 725.56700 |
| Flash Point | 212.5ºC |
| Exact Mass | 724.18000 |
| PSA | 209.82000 |
| LogP | 6.08330 |
| Vapour Pressure | 6.46E-25mmHg at 25°C |
| Storage condition | 2-8℃ |
| Precursor 4 | |
|---|---|
| DownStream 0 | |