KY-556
Modify Date: 2024-01-10 15:54:54
KY-556 structure
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Common Name | KY-556 | ||
|---|---|---|---|---|
| CAS Number | 110816-78-9 | Molecular Weight | 725.56700 | |
| Density | N/A | Boiling Point | 789.7ºC at 760mmHg | |
| Molecular Formula | C33H38Cl2N2O12 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 212.5ºC | |
Use of KY-556KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases. |
| Name | ethyl 5-[2-[(2S)-2,6-diaminohexanoyl]oxy-3-(2-ethoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate,dihydrochloride |
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| Synonym | More Synonyms |
| Description | KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases. |
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| Related Catalog | |
| In Vivo | The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1]. |
| References |
| Boiling Point | 789.7ºC at 760mmHg |
|---|---|
| Molecular Formula | C33H38Cl2N2O12 |
| Molecular Weight | 725.56700 |
| Flash Point | 212.5ºC |
| Exact Mass | 724.18000 |
| PSA | 209.82000 |
| LogP | 6.08330 |
| Vapour Pressure | 6.46E-25mmHg at 25°C |
| Storage condition | 2-8℃ |
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KY-556 CAS#:110816-78-9 |
| Literature: Mori; Nishimura; Tamaki; Nakamura; Tsuda; Kakeya Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 1 p. 338 - 344 |
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KY-556 CAS#:110816-78-9 |
| Literature: Mori; Nishimura; Tamaki; Nakamura; Tsuda; Kakeya Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 1 p. 338 - 344 |
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KY-556 CAS#:110816-78-9 |
| Literature: Mori; Nishimura; Tamaki; Nakamura; Tsuda; Kakeya Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 1 p. 338 - 344 |
|
~%
KY-556 CAS#:110816-78-9 |
| Literature: Mori; Nishimura; Tamaki; Nakamura; Tsuda; Kakeya Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 1 p. 338 - 344 |
![2-[N,N'-di(tert-butoxycarbonyl)-L-lysyloxy]-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane structure](https://image.chemsrc.com/caspic/263/110838-56-7.png)
| 2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride |
| ethyl 5-[2-[(2S)-2,6-diaminohexanoyl]oxy-3-(2-ethoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate dihydrochloride |
| diethyl L-lysylcromoglycate dihydrochloride |
| Cromoglicate lisetil hydrochloride (JAN) |
| 1,3-Bis-(2-ethoxycarbonylchromon-5-yloxy)-2-(lysyloxy)propane |
| KY 556 |
| L-Lysine,2-((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)-1-(((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)methyl)ethyl ester,dihydrochloride |
| KY-556 |