140926-75-6
140926-75-6 structure
- Name: NSC5844
- Chemical Name: N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine
- CAS Number: 140926-75-6
- Molecular Formula: C20H16Cl2N4
- Molecular Weight: 383.27400
- Catalog: Signaling Pathways Anti-infection Parasite
- Create Date: 2018-12-16 09:36:54
- Modify Date: 2024-01-21 12:00:46
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NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.
| Name | N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine |
|---|---|
| Synonyms |
N,N'-Bis-(7-chlor-[4]chinolyl)-aethylendiamin
1,2-Ethanediamine,N,N'-bis(7-chloro-4-quinolinyl) N,N'-bis-(7-chloro-[4]quinolyl)-ethylenediamine N1,N2-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine NSC5844 RE640 |
| Description | NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity. |
|---|---|
| Related Catalog | |
| Target |
Parasite[2] |
| In Vitro | NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively[1]. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively[2]. |
| References |
| Molecular Formula | C20H16Cl2N4 |
|---|---|
| Molecular Weight | 383.27400 |
| Exact Mass | 382.07500 |
| PSA | 49.84000 |
| LogP | 5.75980 |
| Hazard Codes | Xi |
|---|
