NSC5844
Modify Date: 2024-01-21 12:00:46
NSC5844 structure
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Common Name | NSC5844 | ||
|---|---|---|---|---|
| CAS Number | 140926-75-6 | Molecular Weight | 383.27400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H16Cl2N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NSC5844NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity. |
| Name | N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine |
|---|---|
| Synonym | More Synonyms |
| Description | NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity. |
|---|---|
| Related Catalog | |
| Target |
Parasite[2] |
| In Vitro | NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively[1]. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively[2]. |
| References |
| Molecular Formula | C20H16Cl2N4 |
|---|---|
| Molecular Weight | 383.27400 |
| Exact Mass | 382.07500 |
| PSA | 49.84000 |
| LogP | 5.75980 |
| Hazard Codes | Xi |
|---|
|
~85%
NSC5844 CAS#:140926-75-6 |
| Literature: Vennerstrom, Jonathan L.; Ellis, William Y.; Ager, Arba L.; Andersen, Steven L.; Gerena, Lucia; Milhous, Wilbur K. Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2129 - 2134 |
|
~%
NSC5844 CAS#:140926-75-6 |
| Literature: Pearson; Jones; Cope Journal of the American Chemical Society, 1946 , vol. 68, p. 1227 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| N,N'-Bis-(7-chlor-[4]chinolyl)-aethylendiamin |
| 1,2-Ethanediamine,N,N'-bis(7-chloro-4-quinolinyl) |
| N,N'-bis-(7-chloro-[4]quinolyl)-ethylenediamine |
| N1,N2-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine |
| NSC5844 |
| RE640 |