1312201-00-5
1312201-00-5 structure
- Name: HA155
- Chemical Name: (Z)-4-[(4-{[3-(4-fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden]methyl}phenoxy)methyl]benzene boronic acid
- CAS Number: 1312201-00-5
- Molecular Formula: C24H19BFNO5S
- Molecular Weight: 463.28600
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2016-04-14 03:32:26
- Modify Date: 2024-01-09 20:01:01
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HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM[1][2][3].
| Name | (Z)-4-[(4-{[3-(4-fluorobenzyl)-2,4-dioxo-1,3-thiazolan-5-yliden]methyl}phenoxy)methyl]benzene boronic acid |
|---|---|
| Synonyms | Boronic acid,B-[4-[[4-[(Z)-[3-[(4-fluorophenyl)Methyl]-2,4-dioxo-5-thiazolidinylidene]Methyl]phenoxy]Methyl]phenyl]- |
| Description | HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 5.7 nM (ATX)[1] |
| In Vitro | HA-155 inhibits ATX by binding to the ATX active site[1]. HA155 completely attenuates the thrombin-mediated increase in platelet-derived LPA in a dose-dependent manner[3]. |
| References |
[1]. Albers HM, et al. Chemical Evolution of Autotaxin Inhibitors. Chem Rev. 2012 May 9;112(5):2593-603. |
| Molecular Formula | C24H19BFNO5S |
|---|---|
| Molecular Weight | 463.28600 |
| Exact Mass | 463.10600 |
| PSA | 112.37000 |
| LogP | 3.25890 |
| RIDADR | NONH for all modes of transport |
|---|