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147127-20-6

147127-20-6 structure

147127-20-6 structure

Name: Tenofovir
Chemical Name: Tenofovir
CAS Number: 147127-20-6
Molecular Formula: C₉H₁₄N₅O₄P
Molecular Weight: 287.212
Catalog: API Synthetic anti-infective drugs Antiviral drugs
Create Date: 2018-02-07 08:00:00
Modify Date: 2026-07-03 11:52:59
Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.

Name	Tenofovir
Synonyms	(R)-9-(2-Phosphonomethoxypropyl)Adenine Tenofovir API D,L-TENOFOVIR 9-Pmpa (R)-Tenofovir tenofovir (anhydrous) Tenofovir (PMPA) GS-1278 (((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid Tenofovir //BP Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, (R) (r)-(((1-(6-amino-1H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid Tenofovir 1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid Tenofovir,TDF,PMPA Tenofovir-d5Q: What is Tenofovir-d5 Q: What is the CAS Number of Tenofovir-d5 tenofotenofovir (anhydrous)vir (anhydrous) Tenofovir, >= Controlled Substance Tenofovir (1.0 mg/mL in Water) [[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- (9CI) (R)-(1-(6-amino-9H-purin-9-yl)propan-2-yloxy)Methylphosphonic acid [[(1R)-2(6-Amino-9H-purin-9-yl)-1-Methylethoxy]Methyl]ph Tenofovir alafenamide-24 Tenofovir(Viread) (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonicacid Tenofovir(ForResechOnly) (R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE Apropovir Tenefovir Fosprotenofovir 1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid Aids-021800 Viread R-PMPA, Tenofovir Tenofovir disoproxil fumate and intermediates Aids021800 MFCD07357269 Tenofovirdisoproxil Intermediate PMPA Tenofovir (R)-9-(2-phosphonomethoxypropyl) adenine Tenofovir tenofovir Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl] Tenofovir Disoproxil Fumate impurity P Tenofovir & Tenofovir Disoproxil Fumate TenofovirQ: What is Tenofovir Q: What is the CAS Number of Tenofovir Q: What is the storage condition of Tenofovir Q: What e the applications of Tenofovir 107-5 (Undefined stereochemistry) enofovir(anhydrous) enofovir (R)-(((1-(6-AMINO-9H-PURIN-9-YL)PROPAN-2-YL)OXY)METHYL)PHOSPHONIC (R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid (R)-9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) Tenofovir free base (R)-(1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonic acid 206-8 (Hydrate) Tenofovi (R)-PMPA 1-(6-AMinopurin-9-yl)propan-2-yloxyMethylphosphonic acid(PMPA) (1R)-9-(2-Phosphonylmethoxypropyl)-adenine (PMPA TENOFOVIR

Description	Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection
In Vitro	Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC50 values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 μM) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mitochondrial damage[1]. Tenofovir and M48U1 formulated in 0.25% HEC each inhibits the replication of both R5-tropic HIV-1BaL and X4-tropic HIV-1IIIb in activated PBMCs, and inhibits several laboratory strains and patient-derived HIV-1 isolates. The combined formulation of M48U1 and tenofovir in 0.25% HEC exhibits synergistic antiretroviral activity against infection with R5-tropic HIV-1BaL, and is not toxic to PBMCs[2].
In Vivo	Tenofovir Disoproxil Fumarate (20, 50, 140, or 300 mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50, 140, 300 mg/kg) significantly reduces HIV transmission in BLT mice[3]. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection[4].
Cell Assay	Cells are plated into 48-well tissue culture plates (39,000 cells/mL) and allowed to grow for 48 h followed by treatment with vehicle or Tenofovir. Following the treatment period, cell viability is assessed using the MTT assay. The MTT assay relies on the conversion of tetrazolium dye 3-(4,5-dimethlthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to formazan by NAD(P)H-dependent oxidoreductases[1].
Animal Admin	Twenty adult chronic WHV carrier woodchucks are stratified equally by age, sex, body weight, and serum GGT activity into five treatment groups consisting of four animals each: (i) Tenofovir Disoproxil Fumarate at 15.0 mg/kg once per day, (ii) Tenofovir Disoproxil Fumarate at 5.0 mg/kg/day, (iii) Tenofovir Disoproxil Fumarate at 1.5 mg/kg/day, (iv) Tenofovir Disoproxil Fumarate at 0.5 mg/kg/day, and (v) a placebo control. The woodchucks are treated daily for 4 weeks and observed for an additional 12 weeks following cessation of drug treatment[4].
References	[1]. Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3). [2]. Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018. [3]. Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098. [4]. Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8.

Density	1.8±0.1 g/cm3
Boiling Point	616.1±65.0 °C at 760 mmHg
Melting Point	276-280°C
Molecular Formula	C₉H₁₄N₅O₄P
Molecular Weight	287.212
Flash Point	326.4±34.3 °C
Exact Mass	287.078339
PSA	146.19000
LogP	-1.71
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.740
Storage condition	Store at -20°C
Water Solubility	13.4 mg/mL (25 ºC)

Hazard Codes	C
Risk Phrases	R34:Causes burns.
Safety Phrases	S22-S26-S27-S36/37/39-S45
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS	DB8930000
Packaging Group	III
Hazard Class	8
HS Code	2933990090

Precursor 9
180587-75-1 31618-90-3 14047-28-0 17435-30-2
180587-74-0 66224-66-6 160616-02-4 160616-03-5
627510-49-0
DownStream 2
202138-50-9 379270-37-8

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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