Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: Sumatriptan
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Purity: 98.0%
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103628-46-2

103628-46-2 structure

Name: Sumatriptan
Chemical Name: sumatriptan
CAS Number: 103628-46-2
Molecular Formula: C₁₄H₂₁N₃O₂S
Molecular Weight: 295.400
Catalog: API Antipyretic analgesics Anti-migraine drug
Create Date: 2018-07-20 14:27:55
Modify Date: 2026-07-01 06:12:04
Sumatriptan (GR 43175 free base) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan can be used for migraine headache research[1][2].

Name	sumatriptan
Synonyms	Sumatriptan for system suitability CRS 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide 43175 1-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide Sumatriptan (base and/or unspecified salts) 4-HYDRAZINE-N-METHYLBENZENE METHANE SULFONAMIDE IMIGRAN Sumatriptan (50 mg) 3-(2-(dimethylamino)ethyl)-n-methyl-1h-indole-5-methanesulfonamid 3-[2-(Dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide Sumatriptan - Bio-X methylene (2S,5R,6R)-6-[[(2R)-[[[(2S,5R,6R)-6-[[(2R)- aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia- 1-azabicyclo[3.2.0]ht-2-yl]carbonyl]amino]- phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]htane-2-cboxylate (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]htane-2-cboxylate (ampicillin sultamicillin amide) [3-(2-Dimethylaminoethyl)-1H-indole-5-yl]-N-methylmethanesulfonamide (3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide 1-[3-[2-(Dimethylamino)ethyl]-5-indolyl]-N-methylmethanesulfonamide Sumatriptan //BP 43175x sumatriptan hemisuccinate SuMatriptan IMpurity H GR 43175C IMITREX 1H-Indole-5-methanesulfonamide, -(dimethylamino)ethyl-N-methyl Imian，Imitrex 3-[2-(DIMETHYLAMINO)ETHYL]-N-METHYL-1H-INDOLE-5-METHANESULFONAMIDE, SUCCINATE SumatriptanQ: What is Sumatriptan Q: What is the CAS Number of Sumatriptan Q: What is the storage condition of Sumatriptan 3-[2-(Dimethyl amino) ethyl -1H-indol-5-yl -N-methyl methane sulphonamide SuMatriptan Succinate Inj SuMatriptan Maxalt SUMATRIPTAN BASE MFCD00902856 IMIAN 1-{3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide SumatriptanSuccinateBase

Description	Sumatriptan (GR 43175 free base) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan can be used for migraine headache research[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1A Receptor:100 nM (Ki) 5-HT1B Receptor:27 nM (Ki) 5-HT1D Receptor:17 nM (Ki)
References	[1]. S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163(1):133-6. [2]. K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43(5):776-98.

Density	1.2±0.1 g/cm3
Boiling Point	497.7±55.0 °C at 760 mmHg
Melting Point	169-171°C
Molecular Formula	C₁₄H₂₁N₃O₂S
Molecular Weight	295.400
Flash Point	254.8±31.5 °C
Exact Mass	295.135437
PSA	73.58000
LogP	0.67
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.610
Storage condition	2-8°C
Water Solubility	21.4 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL9482200

CHEMICAL NAME :: 1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-

CAS REGISTRY NUMBER :: 103628-46-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C14-H21-N3-O2-S

MOLECULAR WEIGHT :: 295.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 86 mg/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction) Cardiac - EKG changes not diagnostic of specified effects

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 304,1415,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 429 ug/kg/2W-I

TOXIC EFFECTS :: Behavioral - muscle weakness

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 341,1091,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 120 ug/kg

TOXIC EFFECTS :: Behavioral - muscle weakness

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 341,1091,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 240 ug/kg/1H-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - hallucinations, distorted perceptions

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 343,1105,1994

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 14,959,1995

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 14,959,1995

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >20 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - respiratory stimulation Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 14,959,1995

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - ataxia Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 14,959,1995

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 14,959,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11648 mg/kg/26W-I

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 14,959,1995 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 146 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Reproductive - Tumorigenic effects - testicular tumors

REFERENCE :: HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 14,959,1995

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39-S45-S28A
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS	NL9482200
HS Code	29280090

Precursor 9
19718-92-4 139272-29-0 795298-24-7 648909-52-8
61-54-1 50-00-0 88919-22-6 103628-60-0
153654-26-3
DownStream 2
212069-94-8 103628-48-4

HS Code	29280090

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