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China
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Shanghai Jizhi Biochemical Technology Co., Ltd
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DC Chemicals Limited
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Product Name: 1-Hydroxyanthraquinone
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Hydroxy anthraquinone
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129-43-1

129-43-1 structure

129-43-1 structure

Name: 1-HYDROXYANTHRAQUINONE
Chemical Name: 1-hydroxyanthraquinone
CAS Number: 129-43-1
Molecular Formula: C₁₄H₈O₃
Molecular Weight: 224.212
Catalog: Organic raw materials Terpenoid
Create Date: 2018-02-23 08:00:00
Modify Date: 2024-01-02 13:11:37
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1].

Name	1-hydroxyanthraquinone
Synonyms	9,10-Anthracenedione, 1-hydroxy- EINECS 204-946-7 1-HYDROXYANTHRAQUINONE 1-hydroxyanthracene-9,10-dione 1-Hydroxy-9,10-anthraquinone HYDROXY-9,10-ANTHRACENEDIONE MFCD00058946 1-Hydroxy anthraquinone

Description	1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vivo	1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1]. Animal Model: Thirty rats[1]. Dosage: 1% HA in diet. Administration: Diet. Result: Associated with decreased weight gain which was particularly marked towards the termination of experiment. One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon. Seven animals of the group died spontaneously or were sacrificed upon becomingmoribund between 335 and 462 days. A total of 21 rats of group 1 survived until the end of experiment (mean value of totalintake of HA/rat was 76.8 g).
References	[1]. H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802.

Density	1.4±0.1 g/cm3
Boiling Point	414.8±14.0 °C at 760 mmHg
Melting Point	194°C
Molecular Formula	C₁₄H₈O₃
Molecular Weight	224.212
Flash Point	218.8±16.6 °C
Exact Mass	224.047348
PSA	54.37000
LogP	3.97
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.695

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB7178000

CHEMICAL NAME :: Anthraquinone, 1-hydroxy-

CAS REGISTRY NUMBER :: 129-43-1

BEILSTEIN REFERENCE NO. :: 1912751

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H8-O3

MOLECULAR WEIGHT :: 224.22

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 288 gm/kg/68W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 147 gm/kg/42W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 50 umol/L

REFERENCE :: CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,457,1986

Hazard Codes	Xn
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36/37/39
RTECS	CB7178000
Packaging Group	III
HS Code	2914690090

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%