Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(4-Methyoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

872254-32-5

872254-32-5 structure

872254-32-5 structure

Name: NSCI
Chemical Name: 1-[(4-methoxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
CAS Number: 872254-32-5
Molecular Formula: C₂₆H₂₅N₃O₆S
Molecular Weight: 507.55800
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2017-08-25 06:43:23
Modify Date: 2022-06-26 20:53:45
Caspase-3-IN-1 (compound 11b) is a potent Caspase-3 inhibitor, with an IC50 of 14.5 nM[1].

Name	1-[(4-methoxyphenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Synonyms	Pyridine Analogue 21c

Description	Caspase-3-IN-1 (compound 11b) is a potent Caspase-3 inhibitor, with an IC50 of 14.5 nM[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	Caspase-3:14.5 ± 1.6 nM (IC50) Caspase-7:21.8 ± 3.5 nM (IC50) Caspase-6:>5000 nM (IC50) Caspase-1:>10000 nM (IC50) Caspase-8:>50000 nM (IC50)
References	[1]. Chu W, et al. N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies. J Med Chem. 2005 Dec 1;48(24):7637-47.

Molecular Formula	C₂₆H₂₅N₃O₆S
Molecular Weight	507.55800
Exact Mass	507.14600
PSA	114.49000
LogP	4.13550

RIDADR	NONH for all modes of transport