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  • BioBioPha
  • China
  • Product Name: Chebulagic acid
  • Price: ¥Inquiry/5mg
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng


23094-71-5

23094-71-5 structure
23094-71-5 structure
  • Name: Chebulagic acid
  • Chemical Name: 1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose
  • CAS Number: 23094-71-5
  • Molecular Formula: C41H30O27
  • Molecular Weight: 954.661
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-05-25 08:00:00
  • Modify Date: 2024-01-04 23:09:18
  • Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis.target: COX-LOX [1]In vitro: Chebulagic acid can enhance the autophagy. Chebulagic acid exert anti-inflammatory and anti-infective effects. [1] [2] Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. Furthermore, LPS-activated MAPK signaling is inhibited by CA treatment in the EA.hy926 cells. [3]

Name 1-O-galloyl-2,4-O-chebuloyl-3,6-O-HHDP-β-D-glucose
Synonyms Chebulagic acid
[(4R,5S,7R,25S,26R,29S,30S,31S)-13,14,15,18,19,20,31,35,36-Nonahydroxy-2,10,23,28,32-pentaoxo-5-[(3,4,5-trihydroxybenzoyl)oxy]-3,6,9,24,27,33-hexaoxaheptacyclo[28.7.1.0.0.0.0 .0]octatriaconta-1(38),11,13,15,17,19,21,34,36-nonaen-29-yl]acetic acid
10,24-(Epoxymethano)-11H-4,9,12,23,25-pentaoxadibenzo[5',6':7',8']cyclododeca[1',2':7,8]cycloundeca[1,2,3-de]naphthalene-7-acetic acid, 5,6,6a,7,8,9a,10,13,22,23a,24,26-dodecahydro-2,3,6,15,16,17,18,19,20-nonahydroxy-5,8,13,22,26-pentaoxo-27-[(3,4,5-trihydroxybenzoyl)oxy]-, (6S,6aS,7S,9aR,10R,23aS,24R,27S)-
CHEBULAGIC ACID(RG)
Description Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis.target: COX-LOX [1]In vitro: Chebulagic acid can enhance the autophagy. Chebulagic acid exert anti-inflammatory and anti-infective effects. [1] [2] Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. Furthermore, LPS-activated MAPK signaling is inhibited by CA treatment in the EA.hy926 cells. [3]
Related Catalog
References

[1]. Kim HJ et al. Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells. Biomol Ther (Seoul). 2014 Jul;22(4):275-81.

[2]. Liu Y et al. Chebulagic acid inhibits the LPS-induced expression of TNF-α and IL-1β in endothelial cells by suppressing MAPK activation. Exp Ther Med. 2015 Jul;10(1):263-268.

[3]. Athira AP et al. Inhibition of Angiogenesis In Vitro by Chebulagic Acid: A COX-LOX Dual Inhibitor. Int J Vasc Med. 2013;2013:843897.

Density 2.1±0.1 g/cm3
Boiling Point 1610.6±65.0 °C at 760 mmHg
Melting Point >300℃
Molecular Formula C41H30O27
Molecular Weight 954.661
Flash Point 480.0±27.8 °C
Exact Mass 954.097473
PSA 447.09000
LogP 2.25
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.876
Storage condition -20°C
RIDADR NONH for all modes of transport
Precursor  0

DownStream  1