162831-31-4

162831-31-4 structure

Name: IEM 1754 2HBr
Chemical Name: 1,5-Pentanediamine, N1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-, hydrobromide
CAS Number: 162831-31-4
Molecular Formula: C₁₆H₃₂Br₂N₂
Molecular Weight: 412.25
Catalog: Biochemical Inhibitor Neuronal Signaling GluR inhibitor
Create Date: 2016-11-30 22:26:01
Modify Date: 2026-07-02 10:52:18
IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].

Name	1,5-Pentanediamine, N1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-, hydrobromide
Synonyms	IEM 1754 dihydrobroMide //BP N-(Tricyclo[3.3.1.1(3,7)]dec-1-ylmethyl)-1,5-pentanediamine dihydrobromide 1,5-PENTANEDIAMINE, N1-(TRICYCLO[3.3.1.13,7]DEC-1-YLMETHYL)-, HYDROBROMIDE 1,5-Pentanediamine, N1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-, hydrobromide (1:2) AOB5933 AMPA rector,channel block,IEM 1754,Ionotropic glutamate rectors,voltage dendence,IEM1754,inhibit,iGluR,Inhibitor,IEM 1754 2HBr,NMDA rector,IEM-1754 N1-((3r,5r,7r)-Adamantan-1-ylmethyl)pentane-1,5-diamine hydrobromide IEM1754 IEM 1754 2HBr, 10 mM in DMSO N1-(adamantan-1-ylmethyl)pentane-1,5-diamine dihydrobromide IEM1754 DIHYDROBROMIDE;IEM1754 2 HBR; AOB5933 1,5-Pentanediamine, N-(tricyclo[3.3.1.1]dec-1-ylmethyl)-, hydrobromide (1:2) IEM 1754 DIHYDROBROMIDE IEM 1754 Dihydrobromide N-(Adamantan-1-ylmethyl)-1,5-pentanediamine dihydrobromide IEM 1754 2HBr ，S2860

Description	IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
References	[1]. Tikhonov DB, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74. [2]. Lukomskaia NIa, et al. [Comparison of the anticonvulsant activity of organic mono- and di-cations and their potential to inhibit NMDA and AMPA glutamate receptors]. Ross Fiziol Zh Im I M Sechenova. 2002 Sep;88(9):1161-71. Russian.