651-48-9

651-48-9 structure

Name: 10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene
Chemical Name: dehydroepiandrosterone sulfate
CAS Number: 651-48-9
Molecular Formula: C₁₉H₂₈O₅S
Molecular Weight: 368.49
Catalog: Research Areas Neurological Disease
Create Date: 2017-11-03 07:56:10
Modify Date: 2024-01-12 13:01:42
Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3].

Name	dehydroepiandrosterone sulfate
Synonyms	Dehydroepiandrosterone 3-sulfate dehydroepiandrosterone 3β-sulfate [3H]-Dehydroepiandrosterone 3-sulfate DHEA-sulphate ANDROST-5-EN-17-ONE,3-(SULFOOXY)-, (3B)- dehydroepiandrosterone 3-sulphate DHEA sulfate

Description	Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Dehydroepiandrosterone sulfate (DHEAS) selectively increased the length of neurites containing the dendritic marker MAP-2[1]. Dehydroepiandrosterone sulfate (DHEAS) has been reported to increase neuronal excitability (firing rate) when directly applied to septal-preoptic neurons[1]. Dehydroepiandrosterone (DHEA) is produced in prodigious quantities by the humanadrenal, principally as the 3-sulfoconjugate DHEA sulfate (DS) during intrauterine life[2]. Dehydroepiandrosterone sulfate (DHEAS) is generally nontoxic and lacks adverse side effects even when it is administered chronically[3].
In Vivo	DHEAS chronic administration produces a dose-dependent effect on performance[3]. Animal Model: Sixty-four male Sprague-Dawley rats, approximately 90 days of age (300-400 g)[3]. Dosage: 5, 10, or 20 mg/kg. Administration: Subcutaneous injection starting 7 days post-surgery and 1 h prior to all behavioral testing. Result: Significantly effective in improving latency to reach the platform as compared to injured rats receiving vehicle.
References	[1]. E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91. [2]. C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7. [3]. Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70.

Density	1.1763 g/ml
Melting Point	190-192 °C (lit.)
Molecular Formula	C₁₉H₂₈O₅S
Molecular Weight	368.49
Exact Mass	368.16600
PSA	89.05000
LogP	4.78710

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8530000

CHEMICAL NAME :: Androst-5-en-17-one, 3-(sulfooxy)-, (3-beta)-

CAS REGISTRY NUMBER :: 651-48-9

LAST UPDATED :: 199604

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H28-O5-S

MOLECULAR WEIGHT :: 368.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 655 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 293 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 25200 ug/kg/28D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Endocrine - effect on menstrual cycle Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 57,912,1992 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12 mg/kg

SEX/DURATION :: female 39 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - biochemical and metabolic Endocrine - androgenic

REFERENCE :: NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 41,806,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 10-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects

REFERENCE :: SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993

Hazard Codes	Xn

Precursor 0
DownStream 2
53-43-0 663-39-8

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