651-48-9

• 常用中文名：Dehydroepiandrosterone sulfate
• 常用英文名：10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene
• CAS号：651-48-9
• 分子式：C₁₉H₂₈O₅S
• 分子量：368.49
• 相关类别： 研究领域 神经疾病
• 发布时间：2017-11-03 07:56:10
• 更新时间：2024-01-12 13:01:42
• 硫酸脱氢表雄酮是一种神经活性神经甾体,通过影响神经元的迁移、树突的树状化和新突触的形成,在大脑发育和衰老中发挥重要作用[1][2][3]。

名称

• 中文名: 硫酸脱氢表雄酮
• 英文名: dehydroepiandrosterone sulfate
• 英文别名: Dehydroepiandrosterone 3-sulfate; dehydroepiandrosterone 3β-sulfate; [3H]-Dehydroepiandrosterone 3-sulfate; DHEA-sulphate; ANDROST-5-EN-17-ONE,3-(SULFOOXY)-, (3B)-; dehydroepiandrosterone 3-sulphate; DHEA sulfate

物化性质

• 密度: 1.1763 g/ml
• 熔点: 190-192 °C (lit.)
• 分子式: C₁₉H₂₈O₅S
• 分子量: 368.49
• 精确质量: 368.16600
• PSA: 89.05000
• LogP: 4.78710
• 储存条件: 20 °C，密封，干燥

生物活性

• 描述: 硫酸脱氢表雄酮是一种神经活性神经甾体,通过影响神经元的迁移、树突的树状化和新突触的形成,在大脑发育和衰老中发挥重要作用[1][2][3]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体外研究: 硫酸脱氢表雄酮(DHEAS)选择性地增加含有树突标记MAP-2的神经轴突的长度[1]。据报道,硫酸脱氢表雄酮(DHEAS)直接应用于视前隔神经元时可增加神经元兴奋性(放电频率)[1]。脱氢表雄酮(DHEA)由人类肾上腺大量产生,主要作为3-磺基共轭DHEA硫酸盐(DS)在胎儿期产生[2]。硫酸脱氢表雄酮(DHEAS)通常无毒,即使长期服用也没有副作用[3]。
• 体内研究: DHEAS慢性给药对性能产生剂量依赖性影响[3]。动物模型：64只雄性Sprague-Dawley大鼠,大约90天大(300-400克)[3]。剂量：5、10或20 mg/kg。给药：术后7天和所有行为测试前1小时开始皮下注射。结果：与接受车辆的受伤大鼠相比,在改善到达平台的潜伏期方面显著有效。
• 参考文献:

  [1]. E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91.

  [2]. C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7.

  [3]. Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BV8530000 CHEMICAL NAME : Androst-5-en-17-one, 3-(sulfooxy)-, (3-beta)- CAS REGISTRY NUMBER : 651-48-9 LAST UPDATED : 199604 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C19-H28-O5-S MOLECULAR WEIGHT : 368.53 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 655 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 293 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 25200 ug/kg/28D-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Endocrine - effect on menstrual cycle Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 57,912,1992 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 12 mg/kg SEX/DURATION : female 39 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - biochemical and metabolic Endocrine - androgenic REFERENCE : NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 41,806,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 200 mg/kg SEX/DURATION : female 10-15 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects REFERENCE : SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 13,414,1993

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