Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM - 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
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Purity: 99.0%
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Contact: Anson

199327-61-2

199327-61-2 structure

Name: Gefitinib impurity 5
Chemical Name: 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one
CAS Number: 199327-61-2
Molecular Formula: C₁₆H₂₁N₃O₄
Molecular Weight: 319.356
Catalog: Research Areas Others
Create Date: 2018-12-27 16:07:39
Modify Date: 2024-01-02 14:51:44
Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

Name	7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one
Synonyms	4(3H)-Quinazolinone, 7-methoxy-6-[3-(4-morpholinyl)propoxy]- 7-Methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(3H)-one 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(1H)-quinazolinone Gefitinib Impurity 17

Description	Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

Hazard Codes	Xi
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%