Gefitinib impurity 5

Modify Date: 2025-08-22 18:43:27

Gefitinib impurity 5 structure	Common Name	Gefitinib impurity 5
	CAS Number	199327-61-2	Molecular Weight	319.356
	Density	1.3±0.1 g/cm3	Boiling Point	564.4±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₁N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	295.2±30.1 °C

Use of Gefitinib impurity 5

Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

Name	7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one
Synonym	More Synonyms

Description	Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

Density	1.3±0.1 g/cm3
Boiling Point	564.4±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₁N₃O₄
Molecular Weight	319.356
Flash Point	295.2±30.1 °C
Exact Mass	319.153198
PSA	76.68000
LogP	0.29
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.611
Storage condition	2~8℃

Hazard Codes	Xi
HS Code	2934999090

Precursor 8
CAS#:184475-35-2 Gefitinib CAS#:246512-44-7 Gefitinib impurity 2 CAS#:64-18-6 Formic Acid CAS#:77287-34-4 (Z)-Methanimidi...
CAS#:214472-41-0 Benzoic acid, 2... CAS#:675126-26-8 Gefitinib impurity 1 CAS#:1208902-96-8 7-methoxy-6-(3'... CAS#:6702-50-7 Methyl isovanillate
DownStream 2
CAS#:847949-49-9 O-Desmethyl gef... CAS#:184475-35-2 Gefitinib