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125-46-2

125-46-2 structure
125-46-2 structure
  • Name: (±)-Usnic acid
  • Chemical Name: usnic acid
  • CAS Number: 125-46-2
  • Molecular Formula: C18H16O7
  • Molecular Weight: 344.315
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-04-15 08:00:00
  • Modify Date: 2024-01-02 06:06:07
  • Usnic acid, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid has excellent anticancer and antimicrobial properties. Usnic acid significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1[1].
Name usnic acid
Synonyms Usnic acid
MFCD00065294
EINECS 231-456-0
(±)-Usnic acid
2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bH)-dione
2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
1,3(2H,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-
Description Usnic acid, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid has excellent anticancer and antimicrobial properties. Usnic acid significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1[1].
Related Catalog
References

[1]. Kim KJ, et al. Effect of Usnic Acid on Osteoclastogenic Activity. J Clin Med. 2018 Oct 12;7(10). pii: E345.
Density 1.5±0.1 g/cm3
Boiling Point 594.8±50.0 °C at 760 mmHg
Melting Point 200°C
Molecular Formula C18H16O7
Molecular Weight 344.315
Flash Point 219.1±23.6 °C
Exact Mass 344.089600
PSA 117.97000
LogP 2.68
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.643
Storage condition 2-8C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HP5270000
CHEMICAL NAME :
1,3(2H,9bH)-dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-
CAS REGISTRY NUMBER :
125-46-2
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C18-H16-O7
MOLECULAR WEIGHT :
344.34
WISWESSER LINE NOTATION :
T B656 CV EV HO FU BHT&&J B1 DV1 JV1 KQ L1 MQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Mammal - species unspecified Cells - not otherwise specified
DOSE/DURATION :
3750 ug/L
REFERENCE :
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 12,280,1970
Hazard Codes Xn:Harmful;
Risk Phrases R22
Safety Phrases S22-S24/25
RTECS HP5270000
HS Code 2917399090
HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Chemsrc provides CAS#:125-46-2 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 125-46-2 | Chemsrc address: https://m.chemsrc.com/en/baike/1189783.html

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