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15500-66-0

15500-66-0 structure
15500-66-0 structure
  • Name: Pancuronium dibromide
  • Chemical Name: pancuronium bromide
  • CAS Number: 15500-66-0
  • Molecular Formula: C35H60Br2N2O4
  • Molecular Weight: 732.67000
  • Catalog: API Anesthetic Agents Skeletal muscle relaxant
  • Create Date: 2018-03-13 08:00:00
  • Modify Date: 2026-07-01 16:12:44
  • Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.Target: nAChRPancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuronium dibromide is a non-depolarizing agent. Pancuronium is a typical non-depolarizing curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is (unlike suxamethonium) a non-depolarizing agent, which means that it causes no spontaneous depolarizations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration [1-3].
Name pancuronium bromide
Synonyms 2b,16b-Dipiperidino-5a-androstane-3a,17b-diol diacetate dimethobromide
1,1’-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis[1-methyl
1,1'-[3α,17β-Bis(acetoxy)-5α-androstane-2β,16β-diyl]bis[1-methylpiperidinium]
PANCURONIUM DIBROMIDE
1,1'-(3A,17B-DIHYDROXY-2B,5A-ANDROSTAN-2B,16B-YLENE) BIS[1-METHYLPIPERIDINIUM] DIACETATE DIBROMIDE
1,1'-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)androstane-2,16-diyl]bis[1-methylpiperidinium]
MFCD00079223
piperidinium]dibromidediacetate
ylene))bis(1-methyl,dibromide,diacetate
Mioblock：Pavulon
2-beta,16-beta-bis(1-methylpiperidinio)androstane-3-alpha,17-beta-diol 3-alpha,17-beta-di(acetate) dibromide
5alpha-androstan-3alpha,17beta-diol,2beta,16beta-dipipecolinio-,dibromide,di
Org-NE 35
1,1'-[(2BETA,3ALPHA,5ALPHA,16BETA,17BETA)-3,17-BIS(ACETYLOXY)ANDROSTANE-2,16-DIYL]BIS[1-METHYLPIPERIDINIUM]DIBROMIDE
Vecuronium Bromide Impurity B
1，1’-[(2β，3α，5α，16β，17β)-3，17-Bis(acetoxy)androstane-2，16-diyl]bis[1-methyl-piperidinium]dibmmide
1,1’-(3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methylpiperidinium)dibro
na97
3-alpha,17-beta-diacetoxy-2-beta,16-beta-dipiperidino-5-alpha-androstanedime
Piperidinium, 1,1'-[(2b,3a,5a,16b,17b)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide (9CI)
pavulon
pancuronium
1,1’-[3alpha,17beta-bis(acetyloxy)-5alpha-androstane-2beta,16beta-diyl]bis[1-m
piperidinium,1,1’-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)andr
1,1'-(3α,17β-Dihydroxy-5α-androstan-2β,16β-ylene)bis[1-MethylpiperidiniuM] DibroMide Diacetate
1,1'-[3α,17β-Bis(acetyloxy)-5α-androstane-2β,16β-diyl]bis[1-methylpiperidin-1-ium]
Pancuronium bromide (Injectable ade)
ethylpiperidinium]dibromide
Piperidinium, 1,1'-[(2b,3a,5a,16b,17b)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide
1,1'-(3alpha,17beta-Bis(acetyloxy)-5alpha-androstane-2beta,16beta-diyl)bis(1-methylpiperidinium) dibromide
PancuroniuM (Pavulon)
1,1'-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3,17-Diacetoxy-10,13-dimethylhexadecahydro-1H-cyclo
mioblock
Piperidinium, 1,1'-(3a,17b-dihydroxy-5a-androstan-2b,16b-ylene)bis[1-methyl-, dibromide, diacetate (8CI)
ylene))bis(1-methyl-,dibromide,diacetate
16-diyl)bis(1-methyl-ostane-dibromide
orgna97
Pancuronium Dibromide - - Calbiochem
Pancuronium Bromide
2beta,16beta-dipiperidino-5alpha-androstane-3alpha,17beta-dioldiacetatedimetho
3alpha,17beta-diacetoxy-2beta,16beta-dipiperidino-5alpha-androstanedimethobrom
thobromide
EINECS 239-532-5
1,1'-(3a,17b-Dihydroxy-5a-androstan-2b,16b-ylene)bis[1-methylpiperidinium] dibromide diacetate
1,1'-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide
1,1'-[(2b,3a,5a,16b,17b)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide
Vecuronium Bromide Impurity 2(Vecuronium Bromide Impurity B)
1,1'-[3α,17β-Bis(acetyloxy)-5α-androstane-2β,16β-diyl]bis(1-methylpiperidinium)
acetic acid [17-acetyloxy-10,13-dimethyl-2,16-bis(1-methyl-1-piperidin-1-iumyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester dibromide
Miobloc
5a-Androstane-3a,17b-diol, 2b,16b-bis(1-methylpiperidinio)-, dibromide, diacetate (8CI)
1,1'-(3α,17β-Dihydroxy-2β,5α-androstan-2β,16β-ylene)bis[1-methylpiperidinium]diacetatedibromide
Resveratrol 3,4&rsquo
piperidinium,1,1’-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylen
2β,16β-Dipiperidino-5α-androstane-3α,17β-diol Diacetate DiMethobroMide
diacetate
3-alpha,17-beta-diacetoxy-2-beta,16-beta-dipiperidino-5-alpha-androstanedimeth
5alpha-androstan-3alpha,17beta-diol,2beta,16beta-dipipecolinio-,dibromide
PANCURONIUM BROMIDE
Description Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.Target: nAChRPancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuronium dibromide is a non-depolarizing agent. Pancuronium is a typical non-depolarizing curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is (unlike suxamethonium) a non-depolarizing agent, which means that it causes no spontaneous depolarizations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration [1-3].
Related Catalog
References

[1]. Fryer, A.D. and J. Maclagan, Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch Pharmacol, 1987. 335(4): p. 367-71.

[2]. Maestrone, E., et al., Extracellular pancuronium affects sodium current in chick embryo sensory neurones. Br J Pharmacol, 1994. 111(1): p. 283-7.

[3]. Lowenick, C.V., et al., Open channel and competitive block of nicotinic receptors by pancuronium and atracurium. Eur J Pharmacol, 2001. 413(1): p. 31-5.
Melting Point 214 - 217ºC
Molecular Formula C35H60Br2N2O4
Molecular Weight 732.67000
Exact Mass 730.29200
PSA 52.60000
LogP 0.03610
Storage condition Desiccate at RT

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TN4930000
CHEMICAL NAME :
Piperidinium, 1,1'-(2-beta,16-beta-(3-alpha,17-beta-dihydroxy-5-alp ha-androstanylene)) bis(1-methyl-, dibromide, diacetate
CAS REGISTRY NUMBER :
15500-66-0
LAST UPDATED :
199504
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C35-H60-N2-O4.2Br
MOLECULAR WEIGHT :
732.79
WISWESSER LINE NOTATION :
L E5 B666TJ A1 E1 FOV1 OOV1 G- AT6KTJ A1& P- AT6KTJ A1 &E 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
143 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage
REFERENCE :
JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 4,275,1980
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
100 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
REFERENCE :
ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year: 59,73,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 77,848,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
202 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 22,187,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
479 ug/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 22,187,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
436 ug/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 22,187,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
153 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,353,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
21200 ug/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 22,187,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
120 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 32,465,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
167 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,353,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,715,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3500 ng/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 32,465,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
16 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,353,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
67 ug/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year: 44,91,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
63 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,715,1971 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
36 ug/kg
SEX/DURATION :
female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 22,187,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4372 No. of Facilities: 63 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 9551 (estimated) No. of Female Employees: 8705 (estimated)
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements Missing Phrase - N15.00950417
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS TN4930000
Packaging Group III
Hazard Class 6.1(b)
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