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7720-39-0

7720-39-0 structure
7720-39-0 structure
  • Name: 2-Aminoimidazole
  • Chemical Name: 1H-Imidazol-2-amine
  • CAS Number: 7720-39-0
  • Molecular Formula: C3H5N3
  • Molecular Weight: 83.092
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2018-03-18 08:00:00
  • Modify Date: 2024-01-02 08:20:36
  • 2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM[1][2][3].

Name 1H-Imidazol-2-amine
Synonyms N-imidazolylamine
EINECS 231-751-4
1H-Imidazol-2-amine
MFCD00792530
2-aminoimidazole
Description 2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM[1][2][3].
Related Catalog
Target

bacteria[1] Ki: 3.6 mM (human arginase I)[3]

References

[1]. Thompson RJ, et, al. Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry. 2012 Dec 11;51(49):9776-8.

[2]. Jacobs L, et, al. 2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms. Biofouling. 2021 Feb 11;1-17.

[3]. Ilies M, et, al. 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J Med Chem. 2010 May 27;53(10):4266-76.

Density 1.3±0.1 g/cm3
Boiling Point 313.1±25.0 °C at 760 mmHg
Molecular Formula C3H5N3
Molecular Weight 83.092
Flash Point 168.9±10.4 °C
Exact Mass 83.048347
PSA 54.70000
LogP -0.59
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.648
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-37/39
HS Code 2933290090

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Literature: Goebel, Michael W.; Roussev, Christo D.; Scheffer, Ute Helvetica Chimica Acta, 2014 , vol. 97, # 2 p. 215 - 227

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Literature: Voegel; Altorfer; Benner Helvetica Chimica Acta, 1993 , vol. 76, # 5 p. 2061 - 2069

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Literature: Journal of the Society of Dyers and Colourists, vol. 38, p. 271 Chem. Zentralbl., , vol. 94, # I p. 844

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Literature: Journal of the Society of Dyers and Colourists, vol. 38, p. 270 Chem. Zentralbl., , vol. 94, # I p. 844

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Detail
Literature: Journal of the Chemical Society, , vol. 115, p. 250

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Literature: Journal of the Chemical Society, , vol. 117, p. 1430

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Detail
Literature: Journal of the Chemical Society, , vol. 115, p. 250
HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%