Name | Clopamide |
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Synonyms |
EINECS 211-261-7
Brinaldix DT-327 4-Chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-, cis- CLOPAMIDUM ChlosudiMepriMyl Adurix MFCD00941495 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethylpiperidin-1-yl)benzamide Aquex 4-Chloro-N-(2,6-dimethylpiperidin-1-yl)-3-sulfamoylbenzamide Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]- Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)- 4-Chloro-N-(2,6-dimethyl-1-piperidinyl)-3-sulfamoylbenzamide |
Description | Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research[1][2]. |
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Related Catalog | |
In Vitro | Clopamide is actively secreted by renal tubular cells and the True Tubular Excretion Fraction (TTEF) value is 10%[3]. |
In Vivo | The venoconstrictor response to bradykinin is attenuated after oral administration of Clopamide (0.5 mg/kg), and by concomitant local infusion of cyclosporine-A (1-10 μg/min) in conscious dogs[4]. |
References |
Density | 1.4±0.1 g/cm3 |
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Melting Point | 244-246ºC |
Molecular Formula | C14H20ClN3O3S |
Molecular Weight | 345.845 |
Exact Mass | 345.091400 |
PSA | 100.88000 |
LogP | 1.59 |
Index of Refraction | 1.613 |
Storage condition | 2-8°C |
Symbol |
GHS08 |
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Signal Word | Danger |
Hazard Statements | H317-H334 |
Precautionary Statements | P261-P280-P284-P304 + P340-P342 + P311 |
Hazard Codes | Xn |
Risk Phrases | R42/43 |
Safety Phrases | 36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 2935009090 |
HS Code | 2935009090 |
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Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |