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1758-68-5

1758-68-5 structure
1758-68-5 structure
  • Name: 1,2-DIAMINOANTHRAQUINONE
  • Chemical Name: 1,2-diaminoanthraquinone
  • CAS Number: 1758-68-5
  • Molecular Formula: C14H10N2O2
  • Molecular Weight: 238.24100
  • Catalog: Chemical reagent Organic reagent Tricyclic compound
  • Create Date: 2018-05-28 08:00:00
  • Modify Date: 2024-01-02 17:35:33
  • 1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO[1][2].

Name 1,2-diaminoanthraquinone
Synonyms EINECS 217-156-2
1,2-diamino-9,10-anthraquinone
1,2-diaminoanthracene-9,10-dione
1,2-diamino-anthraquinon
DAA
MFCD00001219
1,2-Diaminoanthraquinone
1,2-diamino-10-anthracenedione
diamino-anthraquinone
10-Anthracenedione,1,2-diamino-9
Description 1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO[1][2].
Related Catalog
In Vitro 1,2-Diaminoanthraquinone and the product formed upon its reaction with NO, DAA-TZ, can be spectrally resolved using fluorescence spectroscopy and confocal microscopy[1]. Immunofluorescence[1] Cell Line: Raw 264.7 macrophage cells Concentration: 27.4 μM Incubation Time: 20 min Result: Reacted with NO in the presence of oxygen in the intracellular environment to yield DAA-TZ.
References

[1]. María J Marín, et al. Fluorescence of 1,2-diaminoanthraquinone and its nitric oxide reaction product within macrophage cells. Chembiochem. 2011 Nov 4;12(16):2471-7.

[2]. Francisco Galindo, et al. Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in living cells. Photochem Photobiol Sci. 2008 Jan;7(1):126-30.

Density 1.456 g/cm3
Boiling Point 548.8ºC at 760 mmHg
Melting Point 289-291 °C(lit.)
Molecular Formula C14H10N2O2
Molecular Weight 238.24100
Flash Point 285.7ºC
Exact Mass 238.07400
PSA 86.18000
LogP 2.78880
Vapour Pressure 4.26E-12mmHg at 25°C
Index of Refraction 1.757

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB6200000
CHEMICAL NAME :
Anthraquinone, 1,2-diamino-
CAS REGISTRY NUMBER :
1758-68-5
BEILSTEIN REFERENCE NO. :
2125604
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C14-H10-N2-O2
MOLECULAR WEIGHT :
238.26
WISWESSER LINE NOTATION :
L C666 BV IVJ DZ EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CB6200000
HS Code 2922399090
HS Code 2922399090
Summary 2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%