Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5'-O-[BIS(4-METHOXYPHENYL)PHENYLMETHYL]-2'-DEOXY-2'-FLUORO-URIDINE
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Purity: 98.0%
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146954-74-7

146954-74-7 structure

Name: 5'-DMT-2'-F-dU
Chemical Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
CAS Number: 146954-74-7
Molecular Formula: C₃₀H₂₉FN₂O₇
Molecular Weight: 548.559
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-12-19 19:13:15
Modify Date: 2024-01-08 21:22:48
2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity[1].

Name	1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
Synonyms	5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-uridine DMT-2'-F-dU 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro- HG1172 5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine 5'-DMT-2'-F-dU

Description	2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Filovirus
In Vitro	2'-Deoxy-5'-O-DMT-2'-fluorouridine (compound 15h) has 100% inhibition against YFV at 20 mM. 2'-Deoxy-5'-O-DMT-2'-fluorouridine proves to be noncytotoxic at concen-trations up to 20 mM[1].
References	[1]. Christopher McGuigan, et al. Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues. ChemistryOpen. 2016 Jan 21;5(3):227-35.

Hazard Codes	Xi

40615-36-9

56287-17-3

~94%

146954-74-7

Literature: Helvetica Chimica Acta, , vol. 80, # 6 p. 1952 - 1971

56287-17-3

146954-74-7

Literature: WO2003/99840 A1, ; Page 222 ;