15397-12-3

15397-12-3 structure

Name: 2'-C-Methyladenosine
Chemical Name: (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
CAS Number: 15397-12-3
Molecular Formula: C₁₁H₁₅N₅O₄
Molecular Weight: 281.268
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-04-02 08:00:00
Modify Date: 2024-01-11 00:38:03
2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].

Name	(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
Synonyms	2'-C-Methyladenosine 2-(6-amino-purin-9-yl)-5-hydroxymethyl-3-methyl-tetrahydrofuran-3,4-diol 2'-METHYLADENOSINE 2'-C-methyl adenosine Adenosine, 2'-C-methyl-

Description	2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	IC50: 0.3μM (HCV replicon); 1.9 μM (NS5B)[1]
In Vivo	2'-C-Methyladenosine has inhibitory potency for HCV replicon in HB110A cells with an IC50 values of 0.3μM[1]. 2'-C-Methyladenosine inhibits NS5B-catalyzed RNA synthesis with an IC50 values of 1.9 μM[1]. 2′-C-methyladenosine potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[2]