2'-C-Methyladenosine

Modify Date: 2025-08-25 14:57:52

2'-C-Methyladenosine Structure
2'-C-Methyladenosine structure
Common Name 2'-C-Methyladenosine
CAS Number 15397-12-3 Molecular Weight 281.268
Density 1.9±0.1 g/cm3 Boiling Point 643.4±65.0 °C at 760 mmHg
Molecular Formula C11H15N5O4 Melting Point N/A
MSDS N/A Flash Point 342.9±34.3 °C

 Use of 2'-C-Methyladenosine


2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].

 Names

Name (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
Synonym More Synonyms

 2'-C-Methyladenosine Biological Activity

Description 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].
Related Catalog
Target

IC50: 0.3μM (HCV replicon); 1.9 μM (NS5B)[1]

In Vivo 2'-C-Methyladenosine has inhibitory potency for HCV replicon in HB110A cells with an IC50 values of 0.3μM[1]. 2'-C-Methyladenosine inhibits NS5B-catalyzed RNA synthesis with an IC50 values of 1.9 μM[1]. 2′-C-methyladenosine potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[2]

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 643.4±65.0 °C at 760 mmHg
Molecular Formula C11H15N5O4
Molecular Weight 281.268
Flash Point 342.9±34.3 °C
Exact Mass 281.112396
PSA 139.54000
LogP 0.55
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.823

 Synonyms

2'-C-Methyladenosine
2-(6-amino-purin-9-yl)-5-hydroxymethyl-3-methyl-tetrahydrofuran-3,4-diol
2'-METHYLADENOSINE
2'-C-methyl adenosine
Adenosine, 2'-C-methyl-
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