3573-50-0

3573-50-0 structure

Name: 2-Deoxy-D-glucose-6-phosphate
Chemical Name: 2-deoxy-D-glucose 6-phosphate
CAS Number: 3573-50-0
Molecular Formula: C₆H₁₃O₈P
Molecular Weight: 244.14
Catalog: Research Areas Metabolic Disease
Create Date: 2016-04-23 17:33:40
Modify Date: 2024-01-13 20:07:56
2-Deoxy-D-glucose 6-phosphate is an intermediate of 2-deoxy-D-glucose (2-DG) [1]. 2-Deoxy-D-glucose is incorporated into glycogen[2].

Name	2-deoxy-D-glucose 6-phosphate
Synonyms	2-Deoxy-D-glucose-6-phosphate D-lyxo-2-Desoxy-hexose-6-phosphat 2-deoxyglucose-6-phosphate O6-phosphono-D-lyxo-2-deoxy-hexose [(2R,3S,4R)-2,3,4-trihydroxy-6-oxohexyl] dihydrogen phosphate D-lyxo-3,4,5-Trihydroxy-6-phosphonooxy-hexanal [(2R,3S,4R)-2,3,4-trihydroxy-6-keto-hexyl] dihydrogen phosphate O6-Phosphono-D-lyxo-2-desoxy-hexose

Description	2-Deoxy-D-glucose 6-phosphate is an intermediate of 2-deoxy-D-glucose (2-DG) [1]. 2-Deoxy-D-glucose is incorporated into glycogen[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Acting as a D-glucose mimic, 2-deoxy-D-glucose (2-DG) inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-D-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death[3]. The accumulation of 2-deoxyglucose-6-phosphate (2-DG6P), detected using 31P nuclear magnetic resonance spectroscopy, is used to assess glucose uptake before and during insulin stimulation in the isolated perfused heart[4].
References	[1]. Kuo SC, et al. Inhibition by 2-deoxy-D-glucose of synthesis of glycoprotein enzymes by protoplasts of Saccharomyces: relation to inhibition of sugar uptake and metabolism. J Bacteriol. 1972;111(2):419-429. [2]. Doenst T, et al. Complexities underlying the quantitative determination of myocardial glucose uptake with 2-deoxyglucose. J Mol Cell Cardiol. 1998;30(8):1595-1604. [3]. Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29. [4]. Paternostro G, et al. Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. Cardiovasc Res. 1995;30(2):205-211.

1949-89-9

3573-50-0

Literature: Foster et al. Journal of the Chemical Society, 1951 , p. 980,985

3971-45-7

3573-50-0

Literature: Foster et al. Journal of the Chemical Society, 1951 , p. 980,985

146669-00-3

3573-50-0

Literature: Foster et al. Journal of the Chemical Society, 1951 , p. 980,985

907573-39-1

3573-50-0

Literature: Foster et al. Journal of the Chemical Society, 1951 , p. 980,985

Precursor 3
1949-89-9 3971-45-7 146669-00-3
DownStream 0