1036069-26-7

1036069-26-7 structure

Name: RETRA
Chemical Name: 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone,hydrochloride
CAS Number: 1036069-26-7
Molecular Formula: C₁₁H₁₁NO₃S₂
Molecular Weight: 269.34
Catalog: Signaling Pathways Apoptosis MDM-2/p53
Create Date: 2017-09-26 04:04:41
Modify Date: 2024-04-04 13:25:43
RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].

Name	2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone,hydrochloride
Synonyms	RETRA hydrochloride Reactivation of Transcriptional Reporter Activity RETRA

Description	RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
References	[1]. J E Kravchenko, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.